The small molecule JIB-04 disrupts O2 binding in the Fe-dependent histone demethylase KDM4A/JMJD2A

Barbara Cascella; Soon Goo Lee; Sukrit Singh; Joseph M. Jez; Liviu M. Mirica

doi:10.1039/c6cc09882g

The small molecule JIB-04 disrupts O₂ binding in the Fe-dependent histone demethylase KDM4A/JMJD2A

Barbara Cascella, Soon Goo Lee, Sukrit Singh, Joseph M. Jez, Liviu M. Mirica

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23 Scopus citations

Abstract

JIB-04, a specific inhibitor of the O₂-activating, Fe-dependent histone lysine demethylases, is revealed to disrupt the binding of O₂ in KDM4A/JMJD2A through a continuous O₂-consumption assay, X-ray crystal structure data, and molecular docking.

Original language	English
Pages (from-to)	2174-2177
Number of pages	4
Journal	Chemical Communications
Volume	53
Issue number	13
DOIs	https://doi.org/10.1039/c6cc09882g
State	Published - 2017

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title = "The small molecule JIB-04 disrupts O2 binding in the Fe-dependent histone demethylase KDM4A/JMJD2A",

abstract = "JIB-04, a specific inhibitor of the O2-activating, Fe-dependent histone lysine demethylases, is revealed to disrupt the binding of O2 in KDM4A/JMJD2A through a continuous O2-consumption assay, X-ray crystal structure data, and molecular docking.",

author = "Barbara Cascella and Lee, {Soon Goo} and Sukrit Singh and Jez, {Joseph M.} and Mirica, {Liviu M.}",

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AU - Cascella, Barbara

AU - Lee, Soon Goo

AU - Singh, Sukrit

AU - Jez, Joseph M.

AU - Mirica, Liviu M.

N1 - Publisher Copyright: © The Royal Society of Chemistry.

PY - 2017

Y1 - 2017

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AB - JIB-04, a specific inhibitor of the O2-activating, Fe-dependent histone lysine demethylases, is revealed to disrupt the binding of O2 in KDM4A/JMJD2A through a continuous O2-consumption assay, X-ray crystal structure data, and molecular docking.

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U2 - 10.1039/c6cc09882g

DO - 10.1039/c6cc09882g

M3 - Article

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AN - SCOPUS:85012216734

SN - 1359-7345

VL - 53

SP - 2174

EP - 2177

JO - Chemical Communications

JF - Chemical Communications

IS - 13

ER -

The small molecule JIB-04 disrupts O₂ binding in the Fe-dependent histone demethylase KDM4A/JMJD2A

Abstract

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