TY - JOUR
T1 - The skinny on obesity and plasma cell myeloma
T2 - A review of the literature
AU - Carson, K. R.
AU - Bates, M. L.
AU - Tomasson, M. H.
PY - 2014/8
Y1 - 2014/8
N2 - Despite tremendous advances in treatments for myeloma in the past decade, the disease remains incurable in the majority of patients. Here, we review recent data demonstrating an association between obesity and increased risk of myeloma development. This may be due to the pro-inflammatory cytokine profile caused by obesity. Currently, there are no screening or prevention strategies for myeloma, but we propose that obesity-associated inflammatory pathways, or obesity itself, may be amenable to intervention, thereby preventing the transition from pre-malignancy to myeloma. In addition, we suggest that the morbidity, mortality and the significant costs associated with myeloma treatment could be reduced by addressing modifiable risk factors, and that research efforts should explore this novel hypothesis.
AB - Despite tremendous advances in treatments for myeloma in the past decade, the disease remains incurable in the majority of patients. Here, we review recent data demonstrating an association between obesity and increased risk of myeloma development. This may be due to the pro-inflammatory cytokine profile caused by obesity. Currently, there are no screening or prevention strategies for myeloma, but we propose that obesity-associated inflammatory pathways, or obesity itself, may be amenable to intervention, thereby preventing the transition from pre-malignancy to myeloma. In addition, we suggest that the morbidity, mortality and the significant costs associated with myeloma treatment could be reduced by addressing modifiable risk factors, and that research efforts should explore this novel hypothesis.
UR - http://www.scopus.com/inward/record.url?scp=84905709032&partnerID=8YFLogxK
U2 - 10.1038/bmt.2014.71
DO - 10.1038/bmt.2014.71
M3 - Review article
C2 - 24820216
AN - SCOPUS:84905709032
SN - 0268-3369
VL - 49
SP - 1009
EP - 1015
JO - Bone Marrow Transplantation
JF - Bone Marrow Transplantation
IS - 8
ER -