TY - JOUR
T1 - The skinny on Fat
T2 - an enormous cadherin that regulates cell adhesion, tissue growth, and planar cell polarity
AU - Sopko, Richelle
AU - McNeill, Helen
PY - 2009/10/1
Y1 - 2009/10/1
N2 - Fat is an extremely large atypical cadherin involved in the regulation of cell adhesion, tissue growth, and planar cell polarity (PCP). Recent studies have begun to illuminate the mechanisms by which Fat performs these functions during development. Fat relays signals to the Hippo pathway to regulate tissue growth, and to PCP proteins to regulate tissue patterning. In this review we briefly cover the historical data demonstrating that Fat regulates tissue growth and tissue patterning, and then focus on advances in the past three years illuminating the mechanisms by which Fat controls growth and planar polarity in flies and mammals.
AB - Fat is an extremely large atypical cadherin involved in the regulation of cell adhesion, tissue growth, and planar cell polarity (PCP). Recent studies have begun to illuminate the mechanisms by which Fat performs these functions during development. Fat relays signals to the Hippo pathway to regulate tissue growth, and to PCP proteins to regulate tissue patterning. In this review we briefly cover the historical data demonstrating that Fat regulates tissue growth and tissue patterning, and then focus on advances in the past three years illuminating the mechanisms by which Fat controls growth and planar polarity in flies and mammals.
UR - http://www.scopus.com/inward/record.url?scp=70349338886&partnerID=8YFLogxK
U2 - 10.1016/j.ceb.2009.07.001
DO - 10.1016/j.ceb.2009.07.001
M3 - Review article
C2 - 19679459
AN - SCOPUS:70349338886
SN - 0955-0674
VL - 21
SP - 717
EP - 723
JO - Current Opinion in Cell Biology
JF - Current Opinion in Cell Biology
IS - 5
ER -