The Skeletal Stem Cell

Dongsu Park, Jonathan Hoggatt, Francesca Ferraro, David T. Scadden

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

4 Scopus citations


Tissues in mammals are generally maintained by one of two schemas, mature cell replacement by mature cell division or mature cell replenishment from a more immature stem or progenitor population. It is the latter model that applies to bone homeostasis and we will review here the definition of the skeletal stem cell, its relationship to descendent semi-committed osteoprogenitors, and the terminally differentiated mesenchymal cells (MC) that make up the mature bone. In addition, we will discuss the migration of mesenchymal osteoprogenitors, their kinetics in regulation of life-long bone production, and the interaction of bone cells with hematopoietic cells in the bone marrow.

Original languageEnglish
Title of host publicationOsteoporosis
Subtitle of host publicationFourth Edition
PublisherElsevier Inc.
Number of pages21
ISBN (Print)9780124158535
StatePublished - Jun 2013


  • Endosteal niche
  • Hematopoiesis
  • Mesenchymal stem cell (MSC)
  • Nervous system
  • Osteoblastic cell kinetics
  • Osteolineage cells
  • Skeletal stem cell (SSC)
  • Vascular niche


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