The Skeletal Stem Cell

Dongsu Park; Jonathan Hoggatt; Francesca Ferraro; David T. Scadden

doi:10.1016/B978-0-12-415853-5.00007-8

The Skeletal Stem Cell

Dongsu Park, Jonathan Hoggatt, Francesca Ferraro, David T. Scadden

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

4 Scopus citations

Abstract

Tissues in mammals are generally maintained by one of two schemas, mature cell replacement by mature cell division or mature cell replenishment from a more immature stem or progenitor population. It is the latter model that applies to bone homeostasis and we will review here the definition of the skeletal stem cell, its relationship to descendent semi-committed osteoprogenitors, and the terminally differentiated mesenchymal cells (MC) that make up the mature bone. In addition, we will discuss the migration of mesenchymal osteoprogenitors, their kinetics in regulation of life-long bone production, and the interaction of bone cells with hematopoietic cells in the bone marrow.

Original language	English
Title of host publication	Osteoporosis
Subtitle of host publication	Fourth Edition
Publisher	Elsevier Inc.
Pages	127-147
Number of pages	21
ISBN (Print)	9780124158535
DOIs	https://doi.org/10.1016/B978-0-12-415853-5.00007-8
State	Published - Jun 2013

Keywords

Endosteal niche
Hematopoiesis
Mesenchymal stem cell (MSC)
Nervous system
Osteoblastic cell kinetics
Osteolineage cells
Skeletal stem cell (SSC)
Vascular niche

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10.1016/B978-0-12-415853-5.00007-8

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title = "The Skeletal Stem Cell",

abstract = "Tissues in mammals are generally maintained by one of two schemas, mature cell replacement by mature cell division or mature cell replenishment from a more immature stem or progenitor population. It is the latter model that applies to bone homeostasis and we will review here the definition of the skeletal stem cell, its relationship to descendent semi-committed osteoprogenitors, and the terminally differentiated mesenchymal cells (MC) that make up the mature bone. In addition, we will discuss the migration of mesenchymal osteoprogenitors, their kinetics in regulation of life-long bone production, and the interaction of bone cells with hematopoietic cells in the bone marrow.",

keywords = "Endosteal niche, Hematopoiesis, Mesenchymal stem cell (MSC), Nervous system, Osteoblastic cell kinetics, Osteolineage cells, Skeletal stem cell (SSC), Vascular niche",

author = "Dongsu Park and Jonathan Hoggatt and Francesca Ferraro and Scadden, {David T.}",

year = "2013",

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language = "English",

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pages = "127--147",

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T1 - The Skeletal Stem Cell

AU - Park, Dongsu

AU - Hoggatt, Jonathan

AU - Ferraro, Francesca

AU - Scadden, David T.

PY - 2013/6

Y1 - 2013/6

N2 - Tissues in mammals are generally maintained by one of two schemas, mature cell replacement by mature cell division or mature cell replenishment from a more immature stem or progenitor population. It is the latter model that applies to bone homeostasis and we will review here the definition of the skeletal stem cell, its relationship to descendent semi-committed osteoprogenitors, and the terminally differentiated mesenchymal cells (MC) that make up the mature bone. In addition, we will discuss the migration of mesenchymal osteoprogenitors, their kinetics in regulation of life-long bone production, and the interaction of bone cells with hematopoietic cells in the bone marrow.

AB - Tissues in mammals are generally maintained by one of two schemas, mature cell replacement by mature cell division or mature cell replenishment from a more immature stem or progenitor population. It is the latter model that applies to bone homeostasis and we will review here the definition of the skeletal stem cell, its relationship to descendent semi-committed osteoprogenitors, and the terminally differentiated mesenchymal cells (MC) that make up the mature bone. In addition, we will discuss the migration of mesenchymal osteoprogenitors, their kinetics in regulation of life-long bone production, and the interaction of bone cells with hematopoietic cells in the bone marrow.

KW - Endosteal niche

KW - Hematopoiesis

KW - Mesenchymal stem cell (MSC)

KW - Nervous system

KW - Osteoblastic cell kinetics

KW - Osteolineage cells

KW - Skeletal stem cell (SSC)

KW - Vascular niche

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U2 - 10.1016/B978-0-12-415853-5.00007-8

DO - 10.1016/B978-0-12-415853-5.00007-8

M3 - Chapter

AN - SCOPUS:84903014625

SN - 9780124158535

SP - 127

EP - 147

BT - Osteoporosis

PB - Elsevier Inc.

ER -

The Skeletal Stem Cell

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Keywords

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