The seville expert workshop for progress in posttransplant lymphoproliferative disorders

Denis Glotz, Jeremy R. Chapman, Vikas R. Dharnidharka, Douglas W. Hanto, Maria C.R. Castro, Hans H. Hirsch, Véronique Leblond, Aneesh K. Mehta, Bruno Moulin, Antonio Pagliuca, Julio Pascual, Alan B. Rickinson, Francesco P. Russo, Ralf U. Trappe, Angela C. Webster, Andreas O. Zuckermann, Thomas G. Gross

Research output: Contribution to journalReview articlepeer-review

34 Scopus citations

Abstract

: Posttransplant lymphoproliferative disorders (PTLDs) are associated with significant morbidity and mortality among solid-organ transplant patients, but approaches to diagnosis and management vary considerably. An international multidisciplinary panel evaluated current understanding of risk factors and classification systems and developed recommendations to aid in PTLD prevention. We considered evidence on PTLD risk factors including Epstein-Barr virus serostatus and immunosuppression and identified knowledge gaps for future research. Recommendations address prophylactic and preemptive strategies to minimize PTLD development, including modulation of immunosuppression and antiviral drug regimens. Finally, new classification criteria were outlined that may help facilitate standardized reporting and improve our understanding of PTLD.

Original languageEnglish
Pages (from-to)784-793
Number of pages10
JournalTransplantation
Volume94
Issue number8
DOIs
StatePublished - Oct 27 2012

Keywords

  • Epstein-Barr virus infection
  • Immunosuppression
  • Lymphoproliferative disorder
  • Transplantation

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