The selective activation of the cardiac sarcolemmal sodium-calcium exchanger by plasmalogenic phosphatidic acid produced by phospholipase D

Calvin C. Hale, Eric G. Ebeling, Fong F. Hsu, David A. Ford

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

Since plasmalogens are the predominant phospholipid of cardiac sarcolemma, the activation of the sodium-calcium exchanger by either plasmenylethanolamine or plasmalogenic phosphatidic acid generated by phospholipase D was explored. Sodium-calcium exchange activity was 7-fold greater in proteoliposomes comprised of plasmenylethanolamine compared to proteoliposomes comprised of only plasmenylcholine. Phospholipase D treatment of proteoliposomes resulted in 1 mol % conversion of plasmenylcholine or phosphatidylcholine to their respective phosphatidis acid molecular species with a concomitant 8-fold or 2-fold activation of sodium-calcium exchange activity, respectfully. Thus, phospholipase D-mediated hydrolysis of plasmalogens to phosphatidic acid may be an important mechanism for the regulation of the sodium-calcium exchanger.

Original languageEnglish
Pages (from-to)247-251
Number of pages5
JournalFEBS Letters
Volume422
Issue number2
DOIs
StatePublished - Jan 30 1998

Keywords

  • Myocardium
  • Phosphatidic acid
  • Phospholipase D
  • Plasmalogen
  • Sodium-calcium exchange

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