The Secrets of Acinetobacter Secretion

Brent S. Weber, Rachel L. Kinsella, Christian M. Harding, Mario F. Feldman

Research output: Contribution to journalReview articlepeer-review

25 Scopus citations

Abstract

Infections caused by the bacterial pathogen Acinetobacter baumannii are a mounting concern for healthcare practitioners as widespread antibiotic resistance continues to limit therapeutic treatment options. The biological processes used by A. baumannii to cause disease are not well defined, but recent research has indicated that secreted proteins may play a major role. A variety of mechanisms have now been shown to contribute to protein secretion by A. baumannii and other pathogenic species of Acinetobacter, including a type II secretion system (T2SS), a type VI secretion system (T6SS), autotransporter, and outer membrane vesicles (OMVs). In this review, we summarize the current knowledge of secretion systems in Acinetobacter species, and highlight their unique aspects that contribute to the pathogenicity and persistence of these emerging pathogens.

Original languageEnglish
Pages (from-to)532-545
Number of pages14
JournalTrends in Microbiology
Volume25
Issue number7
DOIs
StatePublished - Jul 2017

Keywords

  • Acinetobacter
  • Autotransporters
  • Outer membrane vesicle
  • Secretion systems
  • T2SS
  • T6SS

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