The secreted kinase ROP18 defends toxoplasma's border

Sarah J. Fentress, L. David Sibley

Research output: Contribution to journalReview articlepeer-review

26 Scopus citations

Abstract

Toxoplasma gondii is a highly successful parasite capable of infecting virtually all warm-blooded animals by actively invading nucleated host cells and forming a modified compartment where it replicates within the cytosol. The parasite-containing vacuole provides a safe haven, even in professional phagocytes such as macrophages, which normally destroy foreign microbes. In an effort to eliminate the parasite, the host up-regulates a family of immunity-related p47 GTPases (IRGs), which are recruited to the parasite-containing vacuole, resulting in membrane rupture and digestion of the parasite. To avoid this fate, highly virulent strains of Toxoplasma coat the external surface of their vacuole with a secretory serine/threonine kinase, known as ROP18. At this host-pathogen interface, ROP18 phosphorylates and inactivates IRGs, thereby protecting the parasite from killing. These findings reveal a novel molecular mechanism by which the parasite disarms host innate immunity.

Original languageEnglish
Pages (from-to)693-700
Number of pages8
JournalBioEssays
Volume33
Issue number9
DOIs
StatePublished - Sep 2011

Keywords

  • GTPase
  • Host defense
  • Immunity
  • Protein trafficking
  • Virulence

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