TY - JOUR
T1 - The Second Pediatric Blood and Marrow Transplant Consortium International Consensus Conference on Late Effects after Pediatric Hematopoietic Cell Transplantation
T2 - Defining the Unique Late Effects of Children Undergoing Hematopoietic Cell Transplantation for Immune Deficiencies, Inherited Marrow Failure Disorders, and Hemoglobinopathies
AU - Dietz, Andrew C.
AU - Duncan, Christine N.
AU - Alter, Blanche P.
AU - Bresters, Dorine
AU - Cowan, Morton J.
AU - Notarangelo, Luigi
AU - Rosenberg, Philip S.
AU - Shenoy, Shalini
AU - Skinner, Roderick
AU - Walters, Mark C.
AU - Wagner, John
AU - Baker, K. Scott
AU - Pulsipher, Michael A.
N1 - Publisher Copyright:
© 2017 The American Society for Blood and Marrow Transplantation
PY - 2017/1/1
Y1 - 2017/1/1
N2 - An international consensus conference sponsored by the Pediatric Blood and Marrow Transplant consortium entitled “Late Effects Screening and Recommendations Following Allogeneic Hematopoietic Cell Transplant for Immune Deficiency and Nonmalignant Hematologic Disease” was held in Minneapolis, Minnesota on May 10, 2016 and May 11, 2016. The purpose of the conference was to address the unmet need for greater understanding of and the screening for long-term complications in the growing population of survivors of transplantation for nonmalignant disorders. The conference focused on transplantation for hemoglobinopathy, immune deficiency, and inherited bone marrow syndromes. A multidisciplinary group of experts in the disease areas and transplantation late effects presented the current state of understanding of how the underlying disease, pretransplantation therapies, and transplantation-related factors uniquely interact to influence the development of late toxicities. Recommendations were put forth by the group for the late effects screening of survivors of transplantation for these nonmalignant disorders. The findings and recommendations that came from this conference will be presented in a series of 6 additional manuscripts in the upcoming months. In this manuscript, we explore the need for screening practices specific to the survivors of transplantation for nonmalignant diseases and the methodologic challenges associated with the study of these patients.
AB - An international consensus conference sponsored by the Pediatric Blood and Marrow Transplant consortium entitled “Late Effects Screening and Recommendations Following Allogeneic Hematopoietic Cell Transplant for Immune Deficiency and Nonmalignant Hematologic Disease” was held in Minneapolis, Minnesota on May 10, 2016 and May 11, 2016. The purpose of the conference was to address the unmet need for greater understanding of and the screening for long-term complications in the growing population of survivors of transplantation for nonmalignant disorders. The conference focused on transplantation for hemoglobinopathy, immune deficiency, and inherited bone marrow syndromes. A multidisciplinary group of experts in the disease areas and transplantation late effects presented the current state of understanding of how the underlying disease, pretransplantation therapies, and transplantation-related factors uniquely interact to influence the development of late toxicities. Recommendations were put forth by the group for the late effects screening of survivors of transplantation for these nonmalignant disorders. The findings and recommendations that came from this conference will be presented in a series of 6 additional manuscripts in the upcoming months. In this manuscript, we explore the need for screening practices specific to the survivors of transplantation for nonmalignant diseases and the methodologic challenges associated with the study of these patients.
KW - Hemoglobinopathies
KW - Immune deficiencies
KW - Late effects
KW - Marrow failure disorders
KW - Pediatric allogeneic bone marrow transplantation
UR - http://www.scopus.com/inward/record.url?scp=85006325291&partnerID=8YFLogxK
U2 - 10.1016/j.bbmt.2016.10.004
DO - 10.1016/j.bbmt.2016.10.004
M3 - Article
C2 - 27737772
AN - SCOPUS:85006325291
SN - 1083-8791
VL - 23
SP - 24
EP - 29
JO - Biology of Blood and Marrow Transplantation
JF - Biology of Blood and Marrow Transplantation
IS - 1
ER -