TY - JOUR
T1 - The Safety After Fifty Evaluation trial
T2 - Evaluation of the safety and efficacy of antihypertensive therapy with metoprolol in patients 50 to 75 years of age: Study design
AU - Rich, Michael W.
AU - LaPalio, Lawrence
AU - Schork, Anthony
AU - SAFE Coordinators, Coordinators
N1 - Funding Information:
From the Geriatric Cardiology Section, University, the Department of Geriatrics, cine, and the Department of Biostatistics, Medicine and School of Public Health. Supported by a grant from CIBA-GEIGY Corp., Summit, N.J. Reprint requests: Michael W. Rich, MD, Division of Cardiology, Hospital of St. Louis, 216 S. Kingshighway, St. Louis, MO 63110. *Steve Julius, MD, Charles Tifft, MD, Barry Uretsky, MD, Ronald MD, Dorothee Perloff, MD, Raymond Magorien, MD, Stephen MD, and Robert Wilburn, MD.
PY - 1988/7
Y1 - 1988/7
N2 - Hypertension increases in prevalence with advancing age and is a major risk factor for the development of cardiovascular disease in elderly patients. However, the presence of coexisting illness, altered drug metabolism, enhanced susceptibility to drug side effects, and physiologic changes such as reduced plasma volume and lower plasma renin levels make truatment of hypertension in elderly patients more difficult. Nonetheless, several studies have now demonstrated the beneficial effects of antihypertensive drug therapy in older parlents. The Safety After Fifty Evaluation trial was designed to determine the short-term efficacy and tolerabillty of once-daily therapy with the cardioselective β-blocker metoprolol anone or in combination with hydrochlorothiazide in the treatment of mild hypertension in patients 50 to 75 years of age. A total of 24,816 patients were enrolled in the trial by 2821 practicing physicians from across the United States. This article describes the detalls of the Safety After Fiffy Evaluation study design. Results of the trial will be reported separately.
AB - Hypertension increases in prevalence with advancing age and is a major risk factor for the development of cardiovascular disease in elderly patients. However, the presence of coexisting illness, altered drug metabolism, enhanced susceptibility to drug side effects, and physiologic changes such as reduced plasma volume and lower plasma renin levels make truatment of hypertension in elderly patients more difficult. Nonetheless, several studies have now demonstrated the beneficial effects of antihypertensive drug therapy in older parlents. The Safety After Fifty Evaluation trial was designed to determine the short-term efficacy and tolerabillty of once-daily therapy with the cardioselective β-blocker metoprolol anone or in combination with hydrochlorothiazide in the treatment of mild hypertension in patients 50 to 75 years of age. A total of 24,816 patients were enrolled in the trial by 2821 practicing physicians from across the United States. This article describes the detalls of the Safety After Fiffy Evaluation study design. Results of the trial will be reported separately.
UR - http://www.scopus.com/inward/record.url?scp=0023787525&partnerID=8YFLogxK
U2 - 10.1016/0002-8703(88)90104-4
DO - 10.1016/0002-8703(88)90104-4
M3 - Article
C2 - 3293397
AN - SCOPUS:0023787525
SN - 0002-8703
VL - 116
SP - 301
EP - 304
JO - American heart journal
JF - American heart journal
IS - 1 PART 2
ER -