The roles of viruses in brain tumor initiation and oncomodulation

Alexander Kofman, Lucasz Marcinkiewicz, Evan Dupart, Anton Lyshchev, Boris Martynov, Anatolii Ryndin, Elena Kotelevskaya, Jay Brown, David Schiff, Roger Abounader

Research output: Contribution to journalReview articlepeer-review

42 Scopus citations

Abstract

While some avian retroviruses have been shown to induce gliomas in animal models, human herpesviruses, specifically, the most extensively studied cytomegalovirus, and the much less studied roseolovirus HHV-6, and Herpes simplex viruses 1 and 2, currently attract more and more attention as possible contributing or initiating factors in the development of human brain tumors. The aim of this review is to summarize and highlight the most provoking findings indicating a potential causative link between brain tumors, specifically malignant gliomas, and viruses in the context of the concepts of viral oncomodulation and the tumor stem cell origin.

Original languageEnglish
Pages (from-to)451-466
Number of pages16
JournalJournal of Neuro-Oncology
Volume105
Issue number3
DOIs
StatePublished - Dec 2011

Keywords

  • Brain tumors
  • Gliomas
  • Herpesviruses
  • Oncomodulation
  • Progenitors
  • Retroviruses
  • Stem cells
  • Viruses

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