The roles of RASD1 small G proteins and leptin in the activation of TRPC4 transient receptor potential channels

Jinhong Wie; Byung Joo Kim; Jongyun Myeong; Kotdaji Ha; Seung Joo Jeong; Dongki Yang; Euiyong Kim; Ju Hong Jeon; Insuk So

doi:10.1080/19336950.2015.1058454

The roles of RASD1 small G proteins and leptin in the activation of TRPC4 transient receptor potential channels

Jinhong Wie
, Byung Joo Kim
, Jongyun Myeong
, Kotdaji Ha
, Seung Joo Jeong
, Dongki Yang
, Euiyong Kim
, Ju Hong Jeon
, Insuk So

Department of Cell Biology & Physiology

Research output: Contribution to journal › Review article › peer-review

6 Scopus citations

Abstract

TRPC4 is important regulators of electrical excitability in gastrointestinal myocytes, pancreatic β-cells and neurons. Much is known regarding the assembly and function of these channels including TRPC1 as a homotetramer or a heteromultimer and the roles that their interacting proteins play in controlling these events. Further, they are one of the best-studied targets of G protein-coupled receptors and growth factors in general and Gα_i/o and Gα_q protein coupled receptor or epidermal growth factor and leptin in particular. However, our understanding of the roles of small G proteins and leptin on TRPC4 channels is still rudimentary. We discuss potential roles for Rasd1 small G protein and leptin in channel activation in addition to their known role in cellular signaling.

Original language	English
Pages (from-to)	186-195
Number of pages	10
Journal	Channels
Volume	9
Issue number	4
DOIs	https://doi.org/10.1080/19336950.2015.1058454
State	Published - Jan 1 2015

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10.1080/19336950.2015.1058454

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title = "The roles of RASD1 small G proteins and leptin in the activation of TRPC4 transient receptor potential channels",

abstract = "TRPC4 is important regulators of electrical excitability in gastrointestinal myocytes, pancreatic β-cells and neurons. Much is known regarding the assembly and function of these channels including TRPC1 as a homotetramer or a heteromultimer and the roles that their interacting proteins play in controlling these events. Further, they are one of the best-studied targets of G protein-coupled receptors and growth factors in general and Gαi/o and Gαq protein coupled receptor or epidermal growth factor and leptin in particular. However, our understanding of the roles of small G proteins and leptin on TRPC4 channels is still rudimentary. We discuss potential roles for Rasd1 small G protein and leptin in channel activation in addition to their known role in cellular signaling.",

author = "Jinhong Wie and Kim, \{Byung Joo\} and Jongyun Myeong and Kotdaji Ha and Jeong, \{Seung Joo\} and Dongki Yang and Euiyong Kim and Jeon, \{Ju Hong\} and Insuk So",

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T1 - The roles of RASD1 small G proteins and leptin in the activation of TRPC4 transient receptor potential channels

AU - Wie, Jinhong

AU - Kim, Byung Joo

AU - Myeong, Jongyun

AU - Ha, Kotdaji

AU - Jeong, Seung Joo

AU - Yang, Dongki

AU - Kim, Euiyong

AU - Jeon, Ju Hong

AU - So, Insuk

PY - 2015/1/1

Y1 - 2015/1/1

N2 - TRPC4 is important regulators of electrical excitability in gastrointestinal myocytes, pancreatic β-cells and neurons. Much is known regarding the assembly and function of these channels including TRPC1 as a homotetramer or a heteromultimer and the roles that their interacting proteins play in controlling these events. Further, they are one of the best-studied targets of G protein-coupled receptors and growth factors in general and Gαi/o and Gαq protein coupled receptor or epidermal growth factor and leptin in particular. However, our understanding of the roles of small G proteins and leptin on TRPC4 channels is still rudimentary. We discuss potential roles for Rasd1 small G protein and leptin in channel activation in addition to their known role in cellular signaling.

AB - TRPC4 is important regulators of electrical excitability in gastrointestinal myocytes, pancreatic β-cells and neurons. Much is known regarding the assembly and function of these channels including TRPC1 as a homotetramer or a heteromultimer and the roles that their interacting proteins play in controlling these events. Further, they are one of the best-studied targets of G protein-coupled receptors and growth factors in general and Gαi/o and Gαq protein coupled receptor or epidermal growth factor and leptin in particular. However, our understanding of the roles of small G proteins and leptin on TRPC4 channels is still rudimentary. We discuss potential roles for Rasd1 small G protein and leptin in channel activation in addition to their known role in cellular signaling.

UR - https://www.scopus.com/pages/publications/84943797115

U2 - 10.1080/19336950.2015.1058454

DO - 10.1080/19336950.2015.1058454

M3 - Review article

C2 - 26083271

AN - SCOPUS:84943797115

SN - 1933-6950

VL - 9

SP - 186

EP - 195

JO - Channels

JF - Channels

IS - 4

ER -

The roles of RASD1 small G proteins and leptin in the activation of TRPC4 transient receptor potential channels

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