The roles of RASD1 small G proteins and leptin in the activation of TRPC4 transient receptor potential channels

Jinhong Wie; Byung Joo Kim; Jongyun Myeong; Kotdaji Ha; Seung Joo Jeong; Dongki Yang; Euiyong Kim; Ju Hong Jeon; Insuk So

doi:10.1080/19336950.2015.1058454

The roles of RASD1 small G proteins and leptin in the activation of TRPC4 transient receptor potential channels

Jinhong Wie, Byung Joo Kim, Jongyun Myeong, Kotdaji Ha, Seung Joo Jeong, Dongki Yang, Euiyong Kim, Ju Hong Jeon, Insuk So

Department of Cell Biology & Physiology

Research output: Contribution to journal › Review article › peer-review

6 Scopus citations

Abstract

TRPC4 is important regulators of electrical excitability in gastrointestinal myocytes, pancreatic β-cells and neurons. Much is known regarding the assembly and function of these channels including TRPC1 as a homotetramer or a heteromultimer and the roles that their interacting proteins play in controlling these events. Further, they are one of the best-studied targets of G protein-coupled receptors and growth factors in general and Gα_i/o and Gα_q protein coupled receptor or epidermal growth factor and leptin in particular. However, our understanding of the roles of small G proteins and leptin on TRPC4 channels is still rudimentary. We discuss potential roles for Rasd1 small G protein and leptin in channel activation in addition to their known role in cellular signaling.

Original language	English
Pages (from-to)	186-195
Number of pages	10
Journal	Channels
Volume	9
Issue number	4
DOIs	https://doi.org/10.1080/19336950.2015.1058454
State	Published - Jan 1 2015

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10.1080/19336950.2015.1058454

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title = "The roles of RASD1 small G proteins and leptin in the activation of TRPC4 transient receptor potential channels",

abstract = "TRPC4 is important regulators of electrical excitability in gastrointestinal myocytes, pancreatic β-cells and neurons. Much is known regarding the assembly and function of these channels including TRPC1 as a homotetramer or a heteromultimer and the roles that their interacting proteins play in controlling these events. Further, they are one of the best-studied targets of G protein-coupled receptors and growth factors in general and Gαi/o and Gαq protein coupled receptor or epidermal growth factor and leptin in particular. However, our understanding of the roles of small G proteins and leptin on TRPC4 channels is still rudimentary. We discuss potential roles for Rasd1 small G protein and leptin in channel activation in addition to their known role in cellular signaling.",

author = "Jinhong Wie and Kim, {Byung Joo} and Jongyun Myeong and Kotdaji Ha and Jeong, {Seung Joo} and Dongki Yang and Euiyong Kim and Jeon, {Ju Hong} and Insuk So",

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AU - Wie, Jinhong

AU - Kim, Byung Joo

AU - Myeong, Jongyun

AU - Ha, Kotdaji

AU - Jeong, Seung Joo

AU - Yang, Dongki

AU - Kim, Euiyong

AU - Jeon, Ju Hong

AU - So, Insuk

PY - 2015/1/1

Y1 - 2015/1/1

N2 - TRPC4 is important regulators of electrical excitability in gastrointestinal myocytes, pancreatic β-cells and neurons. Much is known regarding the assembly and function of these channels including TRPC1 as a homotetramer or a heteromultimer and the roles that their interacting proteins play in controlling these events. Further, they are one of the best-studied targets of G protein-coupled receptors and growth factors in general and Gαi/o and Gαq protein coupled receptor or epidermal growth factor and leptin in particular. However, our understanding of the roles of small G proteins and leptin on TRPC4 channels is still rudimentary. We discuss potential roles for Rasd1 small G protein and leptin in channel activation in addition to their known role in cellular signaling.

AB - TRPC4 is important regulators of electrical excitability in gastrointestinal myocytes, pancreatic β-cells and neurons. Much is known regarding the assembly and function of these channels including TRPC1 as a homotetramer or a heteromultimer and the roles that their interacting proteins play in controlling these events. Further, they are one of the best-studied targets of G protein-coupled receptors and growth factors in general and Gαi/o and Gαq protein coupled receptor or epidermal growth factor and leptin in particular. However, our understanding of the roles of small G proteins and leptin on TRPC4 channels is still rudimentary. We discuss potential roles for Rasd1 small G protein and leptin in channel activation in addition to their known role in cellular signaling.

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The roles of RASD1 small G proteins and leptin in the activation of TRPC4 transient receptor potential channels

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