TY - JOUR
T1 - The roles of CD137 signaling in atherosclerosis
AU - Jung, In Hyuk
AU - Oh, Goo Taeg
N1 - Publisher Copyright:
Copyright © 2016 The Korean Society of Cardiology.
PY - 2016/11
Y1 - 2016/11
N2 - The tumor necrosis factor receptor superfamily (TNFRSF), which includes CD40, LIGHT, and OX40, plays important roles in the initiation and progression of cardiovascular diseases, involving atherosclerosis. CD137, a member of TNFRSF, is a well-known activation-induced T cell co-stimulatory molecule and has been reported to be expressed in human atherosclerotic plaque lesions, and plays pivotal roles in mediating disease processes. In this review, we focus on and summarize recent advances in mouse studies on the involvement of CD137 signaling in the pathogenesis and plaque stability of atherosclerosis, thereby highlighting a valuable therapeutic target in atherosclerosis.
AB - The tumor necrosis factor receptor superfamily (TNFRSF), which includes CD40, LIGHT, and OX40, plays important roles in the initiation and progression of cardiovascular diseases, involving atherosclerosis. CD137, a member of TNFRSF, is a well-known activation-induced T cell co-stimulatory molecule and has been reported to be expressed in human atherosclerotic plaque lesions, and plays pivotal roles in mediating disease processes. In this review, we focus on and summarize recent advances in mouse studies on the involvement of CD137 signaling in the pathogenesis and plaque stability of atherosclerosis, thereby highlighting a valuable therapeutic target in atherosclerosis.
KW - Atherosclerosis
KW - CD137
KW - Plaque stability
KW - T cell
UR - http://www.scopus.com/inward/record.url?scp=84994673844&partnerID=8YFLogxK
U2 - 10.4070/kcj.2016.46.6.753
DO - 10.4070/kcj.2016.46.6.753
M3 - Review article
AN - SCOPUS:84994673844
SN - 1738-5520
VL - 46
SP - 753
EP - 761
JO - Korean Circulation Journal
JF - Korean Circulation Journal
IS - 6
ER -