The role of thrombolysis in the clinical management of deep vein thrombosis

Radha Krishna Popuri, Suresh Vedantham

Research output: Contribution to journalArticlepeer-review

46 Scopus citations


The cornerstones of current management of deep vein thrombosis (DVT) are the routine use of anticoagulant therapy, graduated elastic compression stockings, and early ambulation. Thrombolytic therapy was previously reserved only for patients with life-, limb-, or organ-threatening complications. However, the postthrombotic syndrome has been increasingly recognized as a frequent and serious long-term complication of DVT. In parallel, endovascular thrombolytic methods have evolved considerably in recent years, prompting discussion and controversy as to whether they should be more liberally used. In some centers, pharmacomechanical catheter-directed thrombolysis is now routinely used in the treatment of acute iliofemoral DVT. Randomized trials are currently under way to determine when the use of pharmacomechanical catheter-directed thrombolysis is appropriate in patients presenting with acute proximal DVT.

Original languageEnglish
Pages (from-to)479-484
Number of pages6
JournalArteriosclerosis, thrombosis, and vascular biology
Issue number3
StatePublished - Mar 2011


  • catheter-directed thrombolysis
  • postthrombotic syndrome
  • thrombolysis
  • venous thrombosis


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