TY - JOUR
T1 - The role of the lymphatic system in cholesterol transport
AU - Huang, Li Hao
AU - Elvington, Andrew
AU - Randolph, Gwendalyn J.
N1 - Publisher Copyright:
� 2015 Huang, Elvington and Randolph.
PY - 2015
Y1 - 2015
N2 - Reverse cholesterol transport (RCT) is the pathway for removal of peripheral tissue cholesterol and involves transport of cholesterol back to liver for excretion, starting from cellular cholesterol efflux facilitated by lipid-free apolipoprotein A1 (ApoA1) or other lipidated high-density lipoprotein (HDL) particles within the interstitial space. Extracellular cholesterol then is picked up and transported through the lymphatic vasculature before entering into bloodstream. There is increasing evidence supporting a role for enhanced macrophage cholesterol efflux and RCT in ameliorating atherosclerosis, and recent data suggest that these processes may serve as better diagnostic biomarkers than plasma HDL levels. Hence, it is important to better understand the processes governing ApoA1 and HDL influx into peripheral tissues from the bloodstream, modification and facilitation of cellular cholesterol removal within the interstitial space, and transport through the lymphatic vasculature. New findings will complement therapeutic strategies for the treatment of atherosclerotic vascular disease.
AB - Reverse cholesterol transport (RCT) is the pathway for removal of peripheral tissue cholesterol and involves transport of cholesterol back to liver for excretion, starting from cellular cholesterol efflux facilitated by lipid-free apolipoprotein A1 (ApoA1) or other lipidated high-density lipoprotein (HDL) particles within the interstitial space. Extracellular cholesterol then is picked up and transported through the lymphatic vasculature before entering into bloodstream. There is increasing evidence supporting a role for enhanced macrophage cholesterol efflux and RCT in ameliorating atherosclerosis, and recent data suggest that these processes may serve as better diagnostic biomarkers than plasma HDL levels. Hence, it is important to better understand the processes governing ApoA1 and HDL influx into peripheral tissues from the bloodstream, modification and facilitation of cellular cholesterol removal within the interstitial space, and transport through the lymphatic vasculature. New findings will complement therapeutic strategies for the treatment of atherosclerotic vascular disease.
KW - Apolipoprotein A1
KW - Atherosclerosis
KW - Cholesterol efflux
KW - Cholesterol reverse transport
KW - High-density lipoprotein modification
KW - High-density lipoprotein transport
KW - Interstitial space
KW - Lymphatics
UR - http://www.scopus.com/inward/record.url?scp=84944731583&partnerID=8YFLogxK
U2 - 10.3389/fphar.2015.00182
DO - 10.3389/fphar.2015.00182
M3 - Review article
C2 - 26388772
AN - SCOPUS:84944731583
SN - 1663-9812
VL - 6
JO - Frontiers in Pharmacology
JF - Frontiers in Pharmacology
IS - SEP
M1 - 182
ER -