The role of Th17 cytokines in primary mucosal immunity

Jay K. Kolls, Shabaana A. Khader

Research output: Contribution to journalArticlepeer-review

133 Scopus citations

Abstract

The T helper type 17 (Th17) lineage of CD4+ T-cells produce several effector molecules including IL-17A, IL-17F, IL-21, and IL-22. In addition to CD4+, αβ T-cells, these cytokines can be produced by natural killer and γδ T-cells. These effector cytokines can be produced rapidly upon infection at mucosal sites and evidence to date strongly implicates that this arm of the immune system plays a critical role in mucosal immunity to many extracellular pathogens. Moreover these cytokines can also coordinate adaptive immunity to some intracellular pathogens. In this review, we will highlight recent progress in our understanding of these cytokines, and mechanisms of their effector function in the mucosa.

Original languageEnglish
Pages (from-to)443-448
Number of pages6
JournalCytokine and Growth Factor Reviews
Volume21
Issue number6
DOIs
StatePublished - Dec 2010

Keywords

  • Infection
  • Mucosa
  • Th17

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