The role of surgical biopsy in the diagnosis of glioma in individuals with neurofibromatosis-1

J. R. Leonard; A. Perry; J. B. Rubin; A. A. King; M. R. Chicoine; D. H. Gutmann

doi:10.1212/01.wnl.0000240076.31298.47

The role of surgical biopsy in the diagnosis of glioma in individuals with neurofibromatosis-1

J. R. Leonard
, A. Perry
, J. B. Rubin
, A. A. King
, M. R. Chicoine
, D. H. Gutmann

Research output: Contribution to journal › Article › peer-review

54 Scopus citations

Abstract

Most gliomas in neurofibromatosis type 1 (NF1) are pilocytic astrocytomas (PAs) of the optic pathway occurring in young children. However, some individuals develop gliomas that lack the typical NF1-associated clinical features or radiographic appearance. We identified 17 atypical presentations from a review of 100 patients with NF1-associated gliomas. Biopsy showed that 9 were not classic PAs. These data highlight the value of biopsy in NF1-associated gliomas with unusual clinical or radiographic presentations.

Original language	English
Pages (from-to)	1509-1512
Number of pages	4
Journal	Neurology
Volume	67
Issue number	8
DOIs	https://doi.org/10.1212/01.wnl.0000240076.31298.47
State	Published - Oct 2006

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abstract = "Most gliomas in neurofibromatosis type 1 (NF1) are pilocytic astrocytomas (PAs) of the optic pathway occurring in young children. However, some individuals develop gliomas that lack the typical NF1-associated clinical features or radiographic appearance. We identified 17 atypical presentations from a review of 100 patients with NF1-associated gliomas. Biopsy showed that 9 were not classic PAs. These data highlight the value of biopsy in NF1-associated gliomas with unusual clinical or radiographic presentations.",

author = "Leonard, \{J. R.\} and A. Perry and Rubin, \{J. B.\} and King, \{A. A.\} and Chicoine, \{M. R.\} and Gutmann, \{D. H.\}",

note = "Funding Information: Supported by Schnuck Markets, Inc. (D.H.G.). ",

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AU - Leonard, J. R.

AU - Perry, A.

AU - Rubin, J. B.

AU - King, A. A.

AU - Chicoine, M. R.

AU - Gutmann, D. H.

N1 - Funding Information: Supported by Schnuck Markets, Inc. (D.H.G.).

PY - 2006/10

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N2 - Most gliomas in neurofibromatosis type 1 (NF1) are pilocytic astrocytomas (PAs) of the optic pathway occurring in young children. However, some individuals develop gliomas that lack the typical NF1-associated clinical features or radiographic appearance. We identified 17 atypical presentations from a review of 100 patients with NF1-associated gliomas. Biopsy showed that 9 were not classic PAs. These data highlight the value of biopsy in NF1-associated gliomas with unusual clinical or radiographic presentations.

AB - Most gliomas in neurofibromatosis type 1 (NF1) are pilocytic astrocytomas (PAs) of the optic pathway occurring in young children. However, some individuals develop gliomas that lack the typical NF1-associated clinical features or radiographic appearance. We identified 17 atypical presentations from a review of 100 patients with NF1-associated gliomas. Biopsy showed that 9 were not classic PAs. These data highlight the value of biopsy in NF1-associated gliomas with unusual clinical or radiographic presentations.

UR - https://www.scopus.com/pages/publications/33750334147

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JO - Neurology

JF - Neurology

IS - 8

ER -

The role of surgical biopsy in the diagnosis of glioma in individuals with neurofibromatosis-1

Abstract

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