The Role of Stereotactic Laser Amygdalohippocampotomy in Mesial Temporal Lobe Epilepsy

Robert E. Gross; Jon T. Willie; Daniel L. Drane

doi:10.1016/j.nec.2015.08.004

The Role of Stereotactic Laser Amygdalohippocampotomy in Mesial Temporal Lobe Epilepsy

Robert E. Gross, Jon T. Willie, Daniel L. Drane

Department of Neurosurgery

Research output: Contribution to journal › Review article › peer-review

62 Scopus citations

Abstract

Stereotactic laser amygdalohippocampotomy (SLAH) uses laser interstitial thermal therapy guided by magnetic resonance thermography. This novel intervention can achieve seizure freedom while minimizing collateral damage compared to traditional open surgery, in patients with mesial temporal lobe epilepsy. An algorithm is presented to guide treatment decisions for initial and repeat procedures in patients with and without mesial temporal sclerosis. SLAH may improve access by medication-refractory patients to effective surgical treatments and thereby decrease medical complications, increase productivity, and minimize socioeconomic consequences in patients with chronic epilepsy.

Original language	English
Pages (from-to)	37-50
Number of pages	14
Journal	Neurosurgery clinics of North America
Volume	27
Issue number	1
DOIs	https://doi.org/10.1016/j.nec.2015.08.004
State	Published - Jan 1 2016

Keywords

Ablation
Anterior temporal lobectomy
Laser
Memory
Mesial temporal lobe epilepsy
Mesial temporal sclerosis
Neuropsychology
Selective amygdalohippocampectomy

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10.1016/j.nec.2015.08.004

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title = "The Role of Stereotactic Laser Amygdalohippocampotomy in Mesial Temporal Lobe Epilepsy",

abstract = "Stereotactic laser amygdalohippocampotomy (SLAH) uses laser interstitial thermal therapy guided by magnetic resonance thermography. This novel intervention can achieve seizure freedom while minimizing collateral damage compared to traditional open surgery, in patients with mesial temporal lobe epilepsy. An algorithm is presented to guide treatment decisions for initial and repeat procedures in patients with and without mesial temporal sclerosis. SLAH may improve access by medication-refractory patients to effective surgical treatments and thereby decrease medical complications, increase productivity, and minimize socioeconomic consequences in patients with chronic epilepsy.",

keywords = "Ablation, Anterior temporal lobectomy, Laser, Memory, Mesial temporal lobe epilepsy, Mesial temporal sclerosis, Neuropsychology, Selective amygdalohippocampectomy",

author = "Gross, {Robert E.} and Willie, {Jon T.} and Drane, {Daniel L.}",

note = "Funding Information: Disclosures: Funding was provided to Emory University by way of a clinical study agreement from Visualase , which developed products related to the research described in this article. In addition, R.E. Gross served as a consultant to Visualase and Medtronic and received compensation for these services. The terms of this arrangement have been reviewed and approved by Emory University in accordance with its conflict of interest policies. D.L. Drane receives funding from the NIH/NINDS ( K02 NS070960 ), which provides support for his work. Publisher Copyright: {\textcopyright} 2016 Elsevier Inc..",

year = "2016",

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doi = "10.1016/j.nec.2015.08.004",

language = "English",

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AU - Gross, Robert E.

AU - Willie, Jon T.

AU - Drane, Daniel L.

N1 - Funding Information: Disclosures: Funding was provided to Emory University by way of a clinical study agreement from Visualase , which developed products related to the research described in this article. In addition, R.E. Gross served as a consultant to Visualase and Medtronic and received compensation for these services. The terms of this arrangement have been reviewed and approved by Emory University in accordance with its conflict of interest policies. D.L. Drane receives funding from the NIH/NINDS ( K02 NS070960 ), which provides support for his work. Publisher Copyright: © 2016 Elsevier Inc..

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N2 - Stereotactic laser amygdalohippocampotomy (SLAH) uses laser interstitial thermal therapy guided by magnetic resonance thermography. This novel intervention can achieve seizure freedom while minimizing collateral damage compared to traditional open surgery, in patients with mesial temporal lobe epilepsy. An algorithm is presented to guide treatment decisions for initial and repeat procedures in patients with and without mesial temporal sclerosis. SLAH may improve access by medication-refractory patients to effective surgical treatments and thereby decrease medical complications, increase productivity, and minimize socioeconomic consequences in patients with chronic epilepsy.

AB - Stereotactic laser amygdalohippocampotomy (SLAH) uses laser interstitial thermal therapy guided by magnetic resonance thermography. This novel intervention can achieve seizure freedom while minimizing collateral damage compared to traditional open surgery, in patients with mesial temporal lobe epilepsy. An algorithm is presented to guide treatment decisions for initial and repeat procedures in patients with and without mesial temporal sclerosis. SLAH may improve access by medication-refractory patients to effective surgical treatments and thereby decrease medical complications, increase productivity, and minimize socioeconomic consequences in patients with chronic epilepsy.

KW - Ablation

KW - Anterior temporal lobectomy

KW - Laser

KW - Memory

KW - Mesial temporal lobe epilepsy

KW - Mesial temporal sclerosis

KW - Neuropsychology

KW - Selective amygdalohippocampectomy

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DO - 10.1016/j.nec.2015.08.004

M3 - Review article

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VL - 27

SP - 37

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JO - Neurosurgery Clinics of North America

JF - Neurosurgery Clinics of North America

SN - 1042-3680

IS - 1

ER -

The Role of Stereotactic Laser Amygdalohippocampotomy in Mesial Temporal Lobe Epilepsy

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Keywords

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