We compare the results of genomic scans conducted with the Haseman- Elston sib-pair method using either (1) the average marker information from several adjacent loci or (2) each marker individually. Under smoothing, the squared sib-pair trait difference is regressed on the average number of alleles shared identical by descent averaged at several adjacent loci. This results in a significant decrease in the number of false-positives when compared to the individual marker approach. Linkage of Q4 to MG4 was found only with smoothing but not the individual marker approach. Overall, smoothing resulted in the loss of two true linkages.

Original languageEnglish
Pages (from-to)1047-1052
Number of pages6
JournalGenetic Epidemiology
Issue number6
StatePublished - 1997


  • Nonparametric linkage analysis
  • Quantitative trait loci


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