TY - JOUR
T1 - The role of small or single-institution prospective studies in thoracic research
AU - Semenkovich, Tara R.
AU - Frye, C. Corbin
AU - Harrison, M. Shea
AU - Subramanian, Melanie
AU - Kozower, Benjamin D.
AU - Meyers, Bryan F.
AU - Puri, Varun
N1 - Funding Information:
Funding: TR Semenkovich was supported by the Barnes Jewish Hospital Foundation and the Division of Cardiothoracic Surgery at Washington University in St. Louis. TR Semenkovich and M Subramanian were supported by National Institutes of Health (NIH) Grant Number 2T32HL7776-21.
Publisher Copyright:
© Journal of Thoracic Disease. All rights reserved.
PY - 2019
Y1 - 2019
N2 - Interventional studies are designed specifically to test the impact of a treatment or management strategy on an outcome of interest. In this article, we will highlight two viewpoints regarding the role of small or single-institution prospective interventional studies within the field of thoracic surgery: first, that these studies are beneficial and can positively impact the field, and second, that these studies can have such significant limitations that they may have no meaningful impact. We will also review elements that can make for successful design and execution of small prospective interventional studies.
AB - Interventional studies are designed specifically to test the impact of a treatment or management strategy on an outcome of interest. In this article, we will highlight two viewpoints regarding the role of small or single-institution prospective interventional studies within the field of thoracic surgery: first, that these studies are beneficial and can positively impact the field, and second, that these studies can have such significant limitations that they may have no meaningful impact. We will also review elements that can make for successful design and execution of small prospective interventional studies.
KW - Prospective studies
KW - Small trials
KW - Thoracic surgery
UR - http://www.scopus.com/inward/record.url?scp=85065186546&partnerID=8YFLogxK
U2 - 10.21037/jtd.2019.01.18
DO - 10.21037/jtd.2019.01.18
M3 - Review article
C2 - 31032073
AN - SCOPUS:85065186546
SN - 2072-1439
VL - 11
SP - S555-S561
JO - Journal of Thoracic Disease
JF - Journal of Thoracic Disease
ER -