The Role of Radiation Therapy for Pancreatic Cancer in the Adjuvant and Neoadjuvant Settings

Shahed N. Badiyan, Jason K. Molitoris, Michael D. Chuong, William F. Regine, Adeel Kaiser

Research output: Contribution to journalReview articlepeer-review

20 Scopus citations

Abstract

Pancreatic cancer is the third leading cause of cancer-related death in the United States. Although surgery remains the only curative treatment, chemotherapy and radiation therapy are frequently used. In the adjuvant setting, radiation is usually delivered with chemotherapy to eradicate residual microscopic or macroscopic disease in the resection bed. Neoadjuvant radiation therapy has become more frequently utilized. This article reviews the historical and modern literature regarding radiation therapy in the neoadjuvant and adjuvant settings, focusing on the evolution of radiation therapy techniques and clinical trials in an attempt to identify patients best suited to receiving radiation therapy.

Original languageEnglish
Pages (from-to)431-453
Number of pages23
JournalSurgical Oncology Clinics of North America
Volume26
Issue number3
DOIs
StatePublished - Jul 2017

Keywords

  • Adjuvant
  • Chemoradiation
  • Neoadjuvant
  • Pancreas cancer
  • Pancreatic cancer
  • Proton therapy
  • Radiation therapy
  • Stereotactic body radiotherapy

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