The role of psychological stress in cancer initiation: clinical relevance and potential molecular mechanisms

Marta Falcinelli; Premal H. Thaker; Susan K. Lutgendorf; Suzanne D. Conzen; Renée L. Flaherty; Melanie S. Flint

doi:10.1158/0008-5472.CAN-21-0684

The role of psychological stress in cancer initiation: clinical relevance and potential molecular mechanisms

Marta Falcinelli, Premal H. Thaker, Susan K. Lutgendorf, Suzanne D. Conzen, Renée L. Flaherty, Melanie S. Flint

Research output: Contribution to journal › Review article › peer-review

13 Scopus citations

Abstract

The hypothesis that the physiological response to psychological stress influences the initiation of cancer is highly controversial. The link between initiating stressors, the psychological stress response, and disease is plausible considering that the stress response is associated with defined physiological outcomes and molecular mechanisms. In light of this, we review the clinical relevance of psychological stress on the risk of cancer, and we propose potential molecular pathways that may link the stress response to early stages of malignant cell transformation.

Original language	English
Journal	Cancer research
Volume	81
Issue number	20
DOIs	https://doi.org/10.1158/0008-5472.CAN-21-0684
State	Published - Oct 15 2021

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title = "The role of psychological stress in cancer initiation: clinical relevance and potential molecular mechanisms",

abstract = "The hypothesis that the physiological response to psychological stress influences the initiation of cancer is highly controversial. The link between initiating stressors, the psychological stress response, and disease is plausible considering that the stress response is associated with defined physiological outcomes and molecular mechanisms. In light of this, we review the clinical relevance of psychological stress on the risk of cancer, and we propose potential molecular pathways that may link the stress response to early stages of malignant cell transformation.",

author = "Marta Falcinelli and Thaker, {Premal H.} and Lutgendorf, {Susan K.} and Conzen, {Suzanne D.} and Flaherty, {Ren{\'e}e L.} and Flint, {Melanie S.}",

note = "Funding Information: Acknowledgments: This work has been partially supported by R01CA246540 and R01CA193249 (SL). Publisher Copyright: {\textcopyright} 2021 American Association for Cancer Research.",

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T2 - clinical relevance and potential molecular mechanisms

AU - Falcinelli, Marta

AU - Thaker, Premal H.

AU - Lutgendorf, Susan K.

AU - Conzen, Suzanne D.

AU - Flaherty, Renée L.

AU - Flint, Melanie S.

PY - 2021/10/15

Y1 - 2021/10/15

N2 - The hypothesis that the physiological response to psychological stress influences the initiation of cancer is highly controversial. The link between initiating stressors, the psychological stress response, and disease is plausible considering that the stress response is associated with defined physiological outcomes and molecular mechanisms. In light of this, we review the clinical relevance of psychological stress on the risk of cancer, and we propose potential molecular pathways that may link the stress response to early stages of malignant cell transformation.

AB - The hypothesis that the physiological response to psychological stress influences the initiation of cancer is highly controversial. The link between initiating stressors, the psychological stress response, and disease is plausible considering that the stress response is associated with defined physiological outcomes and molecular mechanisms. In light of this, we review the clinical relevance of psychological stress on the risk of cancer, and we propose potential molecular pathways that may link the stress response to early stages of malignant cell transformation.

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U2 - 10.1158/0008-5472.CAN-21-0684

DO - 10.1158/0008-5472.CAN-21-0684

M3 - Review article

C2 - 34266894

AN - SCOPUS:85117721292

SN - 0008-5472

VL - 81

JO - Cancer research

JF - Cancer research

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ER -

The role of psychological stress in cancer initiation: clinical relevance and potential molecular mechanisms

Abstract

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