TY - JOUR
T1 - The role of procalcitonin in the diagnosis of meningitis
T2 - A literature review
AU - Velissaris, Dimitrios
AU - Pintea, Martina
AU - Pantzaris, Nikolaos
AU - Spatha, Eirini
AU - Karamouzos, Vassilios
AU - Pierrakos, Charalampos
AU - Karanikolas, Menelaos
N1 - Publisher Copyright:
© 2018 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2018/6/11
Y1 - 2018/6/11
N2 - Objective: To review the current published literature on the use of procalcitonin as a diagnostic and prognostic marker in adult patients with meningitis. Methods: We conducted a PubMed search to identify all relevant publications regarding the diagnostic and prognostic value of serum procalcitonin in patients with a known or suspected central nervous system infection. We also reviewed the bibliographies of all identified manuscripts in an attempt to identify additional relevant references. Results: A significant body of evidence suggests that serum procalcitonin has a promising role and can be a useful biomarker in the assessment of patients with meningitis. Conclusions: Our literature review suggests that data on the role of Cerebrospinal Fluid (CSF) procalcitonin are limited, whereas serum procalcitonin (S–PCT) is probably a useful tool in the evaluation of patients with a known or suspected central nervous system infection and can help distinguish between bacterial and viral meningitis.
AB - Objective: To review the current published literature on the use of procalcitonin as a diagnostic and prognostic marker in adult patients with meningitis. Methods: We conducted a PubMed search to identify all relevant publications regarding the diagnostic and prognostic value of serum procalcitonin in patients with a known or suspected central nervous system infection. We also reviewed the bibliographies of all identified manuscripts in an attempt to identify additional relevant references. Results: A significant body of evidence suggests that serum procalcitonin has a promising role and can be a useful biomarker in the assessment of patients with meningitis. Conclusions: Our literature review suggests that data on the role of Cerebrospinal Fluid (CSF) procalcitonin are limited, whereas serum procalcitonin (S–PCT) is probably a useful tool in the evaluation of patients with a known or suspected central nervous system infection and can help distinguish between bacterial and viral meningitis.
KW - Antibiotic therapy
KW - Bacterial meningitis
KW - Biomarker
KW - Differential diagnosis
KW - Procalcitonin
KW - Viral meningitis
UR - http://www.scopus.com/inward/record.url?scp=85068822998&partnerID=8YFLogxK
U2 - 10.3390/jcm7060148
DO - 10.3390/jcm7060148
M3 - Review article
AN - SCOPUS:85068822998
SN - 2077-0383
VL - 7
JO - Journal of Clinical Medicine
JF - Journal of Clinical Medicine
IS - 6
M1 - 148
ER -