The role of phospholipid-derived mediators including arachidonic acid, its metabolites, and inositol triphosphate and of intracellular Ca2+ in glucose-induced insulin secretion by pancretic islets. / Turk, John; Wolf, Bryan A.; McDaniel, Michael L.In: Progress in Lipid Research, Vol. 26, No. 2, 1987, p. 125-181.
Research output: Contribution to journal › Review article › peer-review
TY - JOUR
T1 - The role of phospholipid-derived mediators including arachidonic acid, its metabolites, and inositol triphosphate and of intracellular Ca2+ in glucose-induced insulin secretion by pancretic islets
AU - Turk, John
AU - Wolf, Bryan A.
AU - McDaniel, Michael L.
N1 - Funding Information: Clarification of the role of the Ca 2-and calmodulin-dependent protein kinase and of protein kinase C in insulin release requires identification of their substrates, factors that modulate their activities and their relationship to the cytoskeleton. The molecular mechanism of the participation of the cytoskeleton in insulin secretion may be clarified by application of new methodolo~c tools such as the cell poker and video-enhanced contrast microscopy. Examination of the possible role of the protein kinesin in the transport of the insulin-containing secretory granule to the plasma membrane may also help to elucidate the molecular mechanism of insulin secretion. 336'3ss'39 Acknowledgements--The authors' studies in the areas described in this manuscript were supported in part by grants from the National Institutes of Health (DK06181, DK03373 and DK34388), the Washington University Diabetes Research and Training Center (NiADOK P60 DK 20579), the Washington University Biomedical Research Support Grants program (BSRG S07 RR05389), the Pharmaceutical Manufacturer's Association Foundation, and the Juvenile Diabetes Foundation. We gratefully acknowledge the superb secretarial assistance of Jennifer Ferrell and Jane Huth.
PY - 1987
Y1 - 1987
UR - http://www.scopus.com/inward/record.url?scp=0023066548&partnerID=8YFLogxK
U2 - 10.1016/0163-7827(87)90010-5
DO - 10.1016/0163-7827(87)90010-5
M3 - Review article
C2 - 3116559
AN - SCOPUS:0023066548
VL - 26
SP - 125
EP - 181
JO - Progress in Lipid Research
JF - Progress in Lipid Research
SN - 0163-7827
IS - 2