TY - JOUR
T1 - The Role of Optical Coherence Tomography Angiography in the Diagnosis and Management of Acute Vogt–Koyanagi–Harada Disease
AU - for the OCTA Study Group
AU - Aggarwal, Kanika
AU - Agarwal, Aniruddha
AU - Mahajan, Sarakshi
AU - Invernizzi, Alessandro
AU - Mandadi, Spoorti Krishna Reddy
AU - Singh, Ramandeep
AU - Bansal, Reema
AU - Dogra, Mangat R.
AU - Gupta, Vishali
N1 - Funding Information:
This work was partly supported by a grant from Department of Science and Technology, India for the development of Centre of Excellence at the Advanced Eye Centre, PGIMER Chandigarh. This work was partly supported by a grant from Department of Science and Technology, India for the development of Centre of Excellence at the Advanced Eye Centre, PGIMER Chandigarh.
Funding Information:
This work was partly supported by a grant from Department of Science and Technology, India for the development of Centre of Excellence at the Advanced Eye Centre, PGIMER Chandigarh.
Publisher Copyright:
© Taylor & Francis Group, LLC.
PY - 2018/1/2
Y1 - 2018/1/2
N2 - Purpose: To report the imaging characteristics of acute Vogt–Koyanagi–Harada (VKH) disease using optical coherence tomography angiography (OCTA). Methods: In this prospective study, patients with acute VKH (n = 10; mean age: 30.5 ± 13.43 years) underwent multimodal imaging (baseline and follow-up) using fundus photography, fluorescein angiography (FA), indocyanine green angiography (ICGA), OCT, and OCTA. The OCTA images were analyzed to assess the retinochoroidal vasculature and compared with other imaging techniques. Results: During the active stage, all eyes showed multiple foci of choriocapillaris flow void that correlated with ICGA. These foci decreased in number and size after initiation of therapy. In one patient, flow void areas reappeared after cessation of therapy without any detectable change on ICGA. This patient soon developed clinical recurrence requiring re-initiation of immunosuppression. Conclusions: OCTA allows high-resolution imaging of inflammatory foci suggestive of choriocapillaris hypoperfusion in acute VKH disease non-invasively. OCTA may be very helpful in the follow-up of such patients.
AB - Purpose: To report the imaging characteristics of acute Vogt–Koyanagi–Harada (VKH) disease using optical coherence tomography angiography (OCTA). Methods: In this prospective study, patients with acute VKH (n = 10; mean age: 30.5 ± 13.43 years) underwent multimodal imaging (baseline and follow-up) using fundus photography, fluorescein angiography (FA), indocyanine green angiography (ICGA), OCT, and OCTA. The OCTA images were analyzed to assess the retinochoroidal vasculature and compared with other imaging techniques. Results: During the active stage, all eyes showed multiple foci of choriocapillaris flow void that correlated with ICGA. These foci decreased in number and size after initiation of therapy. In one patient, flow void areas reappeared after cessation of therapy without any detectable change on ICGA. This patient soon developed clinical recurrence requiring re-initiation of immunosuppression. Conclusions: OCTA allows high-resolution imaging of inflammatory foci suggestive of choriocapillaris hypoperfusion in acute VKH disease non-invasively. OCTA may be very helpful in the follow-up of such patients.
KW - Choriocapillaris
KW - EDI-OCT
KW - indocyanine green angiography
KW - multimodal imaging
KW - optical coherence tomography angiography
KW - Vogt–Koyanagi–Harada syndrome
UR - http://www.scopus.com/inward/record.url?scp=84979030703&partnerID=8YFLogxK
U2 - 10.1080/09273948.2016.1195001
DO - 10.1080/09273948.2016.1195001
M3 - Article
C2 - 27440118
AN - SCOPUS:84979030703
SN - 0927-3948
VL - 26
SP - 142
EP - 153
JO - Ocular Immunology and Inflammation
JF - Ocular Immunology and Inflammation
IS - 1
ER -