The role of nerve growth factor in modulating herpes simplex virus reactivation in vivo

Keith A. Laycock; Robert H. Brady; Steven F. Lee; Patricia A. Osborne; Eugene M. Johnson; Jay S. Pepose

doi:10.1007/BF00186584

The role of nerve growth factor in modulating herpes simplex virus reactivation in vivo

Keith A. Laycock, Robert H. Brady, Steven F. Lee, Patricia A. Osborne, Eugene M. Johnson, Jay S. Pepose

Department of Psychiatry

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14 Scopus citations

Abstract

The role of nerve growth factor (NGF) in the modulation of herpes simplex virus (HSV) latency and reactivation was investigated in a mouse model. To determine whether NGF depletion would reactivate latent virus, concentrated anti-NGF serum antibodies were administered intraperitoneally to latently infected mice for 9 consecutive days. To determine whether NGF given prophylactically could suppress UV-B-induced viral reactivation, mice were irradiated with UV-B while being treated with NGF using diverse regimes over a 4-day period. Following intraperitoneal administration of anti-NGF antibodies, viral shedding was detected in a small number (10%) of mice, but it was not possible to pharmacologically suppress UV-B-induced viral reactivation with NGF. It would appear, therefore, that HSV latency in neurons innervating the cornea can be sustained and disrupted by physiological factors independent of NGF levels.

Original language	English
Pages (from-to)	421-425
Number of pages	5
Journal	Graefe's Archive for Clinical and Experimental Ophthalmology
Volume	232
Issue number	7
DOIs	https://doi.org/10.1007/BF00186584
State	Published - Jul 1994

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title = "The role of nerve growth factor in modulating herpes simplex virus reactivation in vivo",

abstract = "The role of nerve growth factor (NGF) in the modulation of herpes simplex virus (HSV) latency and reactivation was investigated in a mouse model. To determine whether NGF depletion would reactivate latent virus, concentrated anti-NGF serum antibodies were administered intraperitoneally to latently infected mice for 9 consecutive days. To determine whether NGF given prophylactically could suppress UV-B-induced viral reactivation, mice were irradiated with UV-B while being treated with NGF using diverse regimes over a 4-day period. Following intraperitoneal administration of anti-NGF antibodies, viral shedding was detected in a small number (10%) of mice, but it was not possible to pharmacologically suppress UV-B-induced viral reactivation with NGF. It would appear, therefore, that HSV latency in neurons innervating the cornea can be sustained and disrupted by physiological factors independent of NGF levels.",

author = "Laycock, {Keith A.} and Brady, {Robert H.} and Lee, {Steven F.} and Osborne, {Patricia A.} and Johnson, {Eugene M.} and Pepose, {Jay S.}",

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T1 - The role of nerve growth factor in modulating herpes simplex virus reactivation in vivo

AU - Laycock, Keith A.

AU - Brady, Robert H.

AU - Lee, Steven F.

AU - Osborne, Patricia A.

AU - Johnson, Eugene M.

AU - Pepose, Jay S.

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AB - The role of nerve growth factor (NGF) in the modulation of herpes simplex virus (HSV) latency and reactivation was investigated in a mouse model. To determine whether NGF depletion would reactivate latent virus, concentrated anti-NGF serum antibodies were administered intraperitoneally to latently infected mice for 9 consecutive days. To determine whether NGF given prophylactically could suppress UV-B-induced viral reactivation, mice were irradiated with UV-B while being treated with NGF using diverse regimes over a 4-day period. Following intraperitoneal administration of anti-NGF antibodies, viral shedding was detected in a small number (10%) of mice, but it was not possible to pharmacologically suppress UV-B-induced viral reactivation with NGF. It would appear, therefore, that HSV latency in neurons innervating the cornea can be sustained and disrupted by physiological factors independent of NGF levels.

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The role of nerve growth factor in modulating herpes simplex virus reactivation in vivo

Abstract

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