TY - JOUR
T1 - The role of muscle in bone repair
T2 - The cells, signals, and tissue responses to injury
AU - Shah, Krupa
AU - Majeed, Zahraa
AU - Jonason, Jennifer
AU - O'Keefe, Regis J.
N1 - Funding Information:
Acknowledgments The work was supported in part by PHS awards RO1AR048861 (RJO) and P50AR954041 (RJO) Disclosure K Shah declares no conflict of interest. Z Majeed declares no conflict of interest. J Jonason declares no conflict of interest. RJ O’Keefe declares no conflicts of interest.
PY - 2013/6
Y1 - 2013/6
N2 - Bone repair is a complicated process that includes many types of cells, signaling molecules, and growth factors. Fracture healing involves a temporally and spatially regulated biologic process that involves recruitment of stem cells to the injury site, tissue specific differentiation, angiogenesis, and remodeling. In light of its proximity to bone and abundant vascularity, muscle is an important potential source of cells and signals for bone healing. More complete understanding of the role of muscle in bone formation and repair will provide new therapeutic approaches to enhance fracture healing. Recent studies establish that muscle-derived stem cells are able to differentiate into cartilage and bone and can directly participate in fracture healing. The role of muscle-derived stem cells is particularly important in fractures associated with more severe injury to the periosteum. Sarcopenia is a serious consequence of aging, and studies show a strong association between bone mass and lean muscle mass. Muscle anabolic agents may improve function and reduce the incidence of fracture with aging.
AB - Bone repair is a complicated process that includes many types of cells, signaling molecules, and growth factors. Fracture healing involves a temporally and spatially regulated biologic process that involves recruitment of stem cells to the injury site, tissue specific differentiation, angiogenesis, and remodeling. In light of its proximity to bone and abundant vascularity, muscle is an important potential source of cells and signals for bone healing. More complete understanding of the role of muscle in bone formation and repair will provide new therapeutic approaches to enhance fracture healing. Recent studies establish that muscle-derived stem cells are able to differentiate into cartilage and bone and can directly participate in fracture healing. The role of muscle-derived stem cells is particularly important in fractures associated with more severe injury to the periosteum. Sarcopenia is a serious consequence of aging, and studies show a strong association between bone mass and lean muscle mass. Muscle anabolic agents may improve function and reduce the incidence of fracture with aging.
KW - Bone repair
KW - Fracture
KW - Muscle
KW - Muscle derived stem cells
KW - Osteoprogenitors
KW - Periosteum
UR - http://www.scopus.com/inward/record.url?scp=84879097640&partnerID=8YFLogxK
U2 - 10.1007/s11914-013-0146-3
DO - 10.1007/s11914-013-0146-3
M3 - Article
C2 - 23591779
AN - SCOPUS:84879097640
SN - 1544-1873
VL - 11
SP - 130
EP - 135
JO - Current Osteoporosis Reports
JF - Current Osteoporosis Reports
IS - 2
ER -