The role of mhc polymorphism in anti-microbial resistance

Janko Nikolich-Žugich; Daved H. Fremont; Michael J. Miley; Ilhem Messaoudi

doi:10.1016/j.micinf.2004.01.006

The role of mhc polymorphism in anti-microbial resistance

Janko Nikolich-Žugich, Daved H. Fremont, Michael J. Miley, Ilhem Messaoudi

Research output: Contribution to journal › Short survey › peer-review

44 Scopus citations

Abstract

The major histocompatibility complex (mhc)-encoded MHC class I and class II molecules present peptide fragments to T cells at every stage of their life (development, survival, persistence and activation). Thereby, these unusually polymorphic molecules critically influence susceptibility to autoimmune and infectious diseases. Here, we examine the mechanistic relationship between mhc polymorphism and anti-microbial resistance/susceptibility.

Original language	English
Pages (from-to)	501-512
Number of pages	12
Journal	Microbes and Infection
Volume	6
Issue number	5
DOIs	https://doi.org/10.1016/j.micinf.2004.01.006
State	Published - Apr 2004

Keywords

Bm
CDR regions
CTL
Complementarity-determining region of the TCR
Cytotoxic T lymphocytes
Dm
Immunity
MHC
Mhc mutation arising in the murine H-2 haplotype
Pathogen resistance
T-cell receptor

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title = "The role of mhc polymorphism in anti-microbial resistance",

abstract = "The major histocompatibility complex (mhc)-encoded MHC class I and class II molecules present peptide fragments to T cells at every stage of their life (development, survival, persistence and activation). Thereby, these unusually polymorphic molecules critically influence susceptibility to autoimmune and infectious diseases. Here, we examine the mechanistic relationship between mhc polymorphism and anti-microbial resistance/susceptibility.",

keywords = "Bm, CDR regions, CTL, Complementarity-determining region of the TCR, Cytotoxic T lymphocytes, Dm, Immunity, MHC, Mhc mutation arising in the murine H-2 haplotype, Pathogen resistance, T-cell receptor",

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AU - Nikolich-Žugich, Janko

AU - Fremont, Daved H.

AU - Miley, Michael J.

AU - Messaoudi, Ilhem

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AB - The major histocompatibility complex (mhc)-encoded MHC class I and class II molecules present peptide fragments to T cells at every stage of their life (development, survival, persistence and activation). Thereby, these unusually polymorphic molecules critically influence susceptibility to autoimmune and infectious diseases. Here, we examine the mechanistic relationship between mhc polymorphism and anti-microbial resistance/susceptibility.

KW - Bm

KW - CDR regions

KW - CTL

KW - Complementarity-determining region of the TCR

KW - Cytotoxic T lymphocytes

KW - Dm

KW - Immunity

KW - MHC

KW - Mhc mutation arising in the murine H-2 haplotype

KW - Pathogen resistance

KW - T-cell receptor

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DO - 10.1016/j.micinf.2004.01.006

M3 - Short survey

C2 - 15109966

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VL - 6

SP - 501

EP - 512

JO - Microbes and Infection

JF - Microbes and Infection

SN - 1286-4579

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