Abstract
The major histocompatibility complex (mhc)-encoded MHC class I and class II molecules present peptide fragments to T cells at every stage of their life (development, survival, persistence and activation). Thereby, these unusually polymorphic molecules critically influence susceptibility to autoimmune and infectious diseases. Here, we examine the mechanistic relationship between mhc polymorphism and anti-microbial resistance/susceptibility.
Original language | English |
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Pages (from-to) | 501-512 |
Number of pages | 12 |
Journal | Microbes and Infection |
Volume | 6 |
Issue number | 5 |
DOIs | |
State | Published - Apr 2004 |
Keywords
- Bm
- CDR regions
- CTL
- Complementarity-determining region of the TCR
- Cytotoxic T lymphocytes
- Dm
- Immunity
- MHC
- Mhc mutation arising in the murine H-2 haplotype
- Pathogen resistance
- T-cell receptor