The major histocompatibility complex (mhc)-encoded MHC class I and class II molecules present peptide fragments to T cells at every stage of their life (development, survival, persistence and activation). Thereby, these unusually polymorphic molecules critically influence susceptibility to autoimmune and infectious diseases. Here, we examine the mechanistic relationship between mhc polymorphism and anti-microbial resistance/susceptibility.
- CDR regions
- Complementarity-determining region of the TCR
- Cytotoxic T lymphocytes
- Mhc mutation arising in the murine H-2 haplotype
- Pathogen resistance
- T-cell receptor