Osteoarthritis is a progressive joint disease characterised by an imbalance of articular cartilage biosynthesis and degradation attributed to both inflammatory and biomechanical factors. Whereas moderate mechanical loading appears necessary for maintaining healthy cartilage, abnormal joint loading increases the risk of osteoarthritis. Obesity-induced osteoarthritis and the benefits of physical activity may be mediated by systemic levels of proinflammatory mediators as well as local biomechanical factors in the joint.

Original languageEnglish
Pages (from-to)195-200
Number of pages6
JournalExercise and Sport Sciences Reviews
Issue number4
StatePublished - Oct 2005


  • Adipokine
  • Arthritis
  • Biomechanics
  • Chondrocyte
  • Exercise
  • Metabolic syndrome X
  • Obesity


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