@inbook{f9d9395b46bf4ed5a1ad2f2681ef140e,
title = "The role of mammalian sirtuins in the regulation of metabolism, aging, and longevity",
abstract = "Ever since the discovery of sirtuins a decade ago, interest in this family of NAD-dependent deacetylases has exploded, generating multiple lines of evidence implicating sirtuins as evolutionarily conserved regulators of lifespan. In mammals, it has been established that sirtuins regulate physiological responses to metabolism and stress, two key factors that affect the process of aging. Further investigation into the intimate connection among sirtuins, metabolism, and aging has implicated the activation of SIRT1 as both preventative and therapeutic measures against multiple age-associated disorders including type 2 diabetes and Alzheimer's disease. SIRT1 activation has clear potential to not only prevent age-associated diseases but also to extend healthspan and perhaps lifespan. Sirtuin activating compounds and NAD intermediates are two promising ways to achieve these elusive goals.",
keywords = "Age-associated disorders, Aging, Lifespan, NAD intermediates, NAD world, Nicotinamide adenine dinucleotide, Nicotinamide mononucleotide, SIRT1, Sirtuin activating compounds, Sirtuins",
author = "Akiko Satoh and Liana Stein and Shin Imai",
note = "Funding Information: We apologize to those whose work is not cited due to space limitations. L.S. is supported by the NIH training program in cellular and molecular biology (5T32GM007067-36). S.I. is supported by grants from the National Institute of Health (AG024150 and HL097817), Ellison Medical Foundation, and Longer Life Foundation. S.I. serves as a scientific advisory board member for and has a sponsored research agreement with Sirtris pharmaceuticals, a GSK company.",
year = "2011",
doi = "10.1007/978-3-642-21631-2_7",
language = "English",
isbn = "9783642216305",
series = "Handbook of Experimental Pharmacology",
pages = "125--162",
editor = "Tso-Pang Yao and Edward Seto",
booktitle = "Histone Deacetylases",
}