The role of mammalian sirtuins in the regulation of metabolism, aging, and longevity

Akiko Satoh, Liana Stein, Shin Imai

Research output: Chapter in Book/Report/Conference proceedingChapter

84 Scopus citations

Abstract

Ever since the discovery of sirtuins a decade ago, interest in this family of NAD-dependent deacetylases has exploded, generating multiple lines of evidence implicating sirtuins as evolutionarily conserved regulators of lifespan. In mammals, it has been established that sirtuins regulate physiological responses to metabolism and stress, two key factors that affect the process of aging. Further investigation into the intimate connection among sirtuins, metabolism, and aging has implicated the activation of SIRT1 as both preventative and therapeutic measures against multiple age-associated disorders including type 2 diabetes and Alzheimer's disease. SIRT1 activation has clear potential to not only prevent age-associated diseases but also to extend healthspan and perhaps lifespan. Sirtuin activating compounds and NAD intermediates are two promising ways to achieve these elusive goals.

Original languageEnglish
Title of host publicationHistone Deacetylases
Subtitle of host publicationthe Biology and Clinical Implication
EditorsTso-Pang Yao, Edward Seto
Pages125-162
Number of pages38
DOIs
StatePublished - Oct 24 2011
Externally publishedYes

Publication series

NameHandbook of Experimental Pharmacology
Volume206
ISSN (Print)0171-2004
ISSN (Electronic)1865-0325

Keywords

  • Age-associated disorders
  • Aging
  • Lifespan
  • NAD intermediates
  • NAD world
  • Nicotinamide adenine dinucleotide
  • Nicotinamide mononucleotide
  • SIRT1
  • Sirtuin activating compounds
  • Sirtuins

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  • Cite this

    Satoh, A., Stein, L., & Imai, S. (2011). The role of mammalian sirtuins in the regulation of metabolism, aging, and longevity. In T-P. Yao, & E. Seto (Eds.), Histone Deacetylases: the Biology and Clinical Implication (pp. 125-162). (Handbook of Experimental Pharmacology; Vol. 206). https://doi.org/10.1007/978-3-642-21631-2_7