Ever since the discovery of sirtuins a decade ago, interest in this family of NAD-dependent deacetylases has exploded, generating multiple lines of evidence implicating sirtuins as evolutionarily conserved regulators of lifespan. In mammals, it has been established that sirtuins regulate physiological responses to metabolism and stress, two key factors that affect the process of aging. Further investigation into the intimate connection among sirtuins, metabolism, and aging has implicated the activation of SIRT1 as both preventative and therapeutic measures against multiple age-associated disorders including type 2 diabetes and Alzheimer's disease. SIRT1 activation has clear potential to not only prevent age-associated diseases but also to extend healthspan and perhaps lifespan. Sirtuin activating compounds and NAD intermediates are two promising ways to achieve these elusive goals.

Original languageEnglish
Title of host publicationHistone Deacetylases
Subtitle of host publicationthe Biology and Clinical Implication
EditorsTso-Pang Yao, Edward Seto
Number of pages38
StatePublished - 2011

Publication series

NameHandbook of Experimental Pharmacology
ISSN (Print)0171-2004
ISSN (Electronic)1865-0325


  • Age-associated disorders
  • Aging
  • Lifespan
  • NAD intermediates
  • NAD world
  • Nicotinamide adenine dinucleotide
  • Nicotinamide mononucleotide
  • SIRT1
  • Sirtuin activating compounds
  • Sirtuins


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