@article{ceac2c74d86643298032da27b6ab3243,
title = "The role of lipopolysaccharide in T-cell responses following DNA vaccination",
abstract = "Bacterial products, including lipopolysaccharide (LPS), are potential impurities in plasmid DNA vaccines. LPS has immunostimulatory properties even at exceedingly low concentrations through activation of Toll-like receptor 4 (TLR4). The potency of T-cell responses after vaccination was tested with DNA containing high LPS or depleted of LPS in TLR4-competent and TLR4-deficient mice. CD8+ T-cell responses were readily induced in TLR4-deficient mice immunized with DNA depleted of LPS. LPS in DNA vaccines is not required for CD8+ T-cell responses.",
keywords = "DNA vaccination, Lipopolysaccharide, T-cell immunity",
author = "Hawkins, {William G.} and Jiri Trcka and Neil Segal and Blachere, {Nathalie E.} and Gold, {Jason S.} and Yoichi Moroi and Bowne, {Wilbur B.} and Lewis, {Jonathan J.} and Wolchok, {Jedd D.} and Houghton, {Alan N.}",
note = "Funding Information: This work was supported by grants from the National Cancer Institute CA58621, CA33049, CA47179 and CA58350, the Lymphoma Foundation, the Louis and Anne Abrons Foundation, Swim Across America, the Kennedy Family and the Kleberg Foundation. W.G.H., J.S.G. and W.B.B. were supported by NIH Training Grant CA09501. J.S.G. was a Lawrence & Selma Ruben Fellow. ",
year = "2003",
month = mar,
day = "28",
doi = "10.1016/S0264-410X(02)00676-X",
language = "English",
volume = "21",
pages = "1548--1553",
journal = "Vaccine",
issn = "0264-410X",
number = "13-14",
}