What are the indications for irradiation of patients with carcinoma of the endometrium? Carcinoma of the endometrium is the most common invasive gynecological neoplasm in women in the United States. The hallmark of its therapeutic management is hysterectomy. Although adjuvant irradiation has also been utilized, in contradistinction to carcinoma of the uterine cervix, for endometrial carcinoma, irradiation alone is not optimal therapy. The best clinical outcomes for patients with endometrial carcinoma seem to be achieved with either surgery alone or a combination of surgery and irradiation. When irradiation is administered, it is more often postoperative rather than preoperative therapy. Few prospective randomized studies have been performed for patients with endometrial carcinoma, until recently when randomized studies have attempted to answer questions regarding the best management for these patients.
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|Published - Jan 1 2001