TY - JOUR
T1 - The Role of Innate Immune Responses in the Heart in Health and Disease
AU - Knuefermann, Pascal
AU - Vallejo, Jesus
AU - Mann, Douglas L.
N1 - Funding Information:
The authors gratefully acknowledge Ms. Mary Helen Soliz for secretarial assistance. This research was supported by research funds from the Veterans Administration and the National Institutes of Health (P50 HL-O6H, RO1 HL58081-01, RO1 HL61543-01, HL-42250-10/10).
PY - 2004/1
Y1 - 2004/1
N2 - The ability of the myocardium to successfully adapt to environmental stress ultimately determines whether the heart will decompensate and fail, or whether it will maintain preserved function. Despite the importance of the myocardial response to environmental stress, very little is known with respect to the biochemical mechanisms that are responsible for mediating and integrating the stress response in the heart. The present review summarizes recent experimental material that suggests that the heart possesses a germ-line encoded "innate" stress response that is activated in response to diverse forms of tissue injury. The extant literature suggests that this innate stress response plays an important role in initiating and integrating homeostatic responses within the heart. Nonetheless, as will be discussed further herein, these inflammatory mediators all have the potential to produce cardiac decompensation when expressed at sufficiently high concentrations.
AB - The ability of the myocardium to successfully adapt to environmental stress ultimately determines whether the heart will decompensate and fail, or whether it will maintain preserved function. Despite the importance of the myocardial response to environmental stress, very little is known with respect to the biochemical mechanisms that are responsible for mediating and integrating the stress response in the heart. The present review summarizes recent experimental material that suggests that the heart possesses a germ-line encoded "innate" stress response that is activated in response to diverse forms of tissue injury. The extant literature suggests that this innate stress response plays an important role in initiating and integrating homeostatic responses within the heart. Nonetheless, as will be discussed further herein, these inflammatory mediators all have the potential to produce cardiac decompensation when expressed at sufficiently high concentrations.
UR - http://www.scopus.com/inward/record.url?scp=0346055157&partnerID=8YFLogxK
U2 - 10.1016/j.tcm.2003.09.003
DO - 10.1016/j.tcm.2003.09.003
M3 - Review article
C2 - 14720467
AN - SCOPUS:0346055157
SN - 1050-1738
VL - 14
SP - 1
EP - 7
JO - Trends in Cardiovascular Medicine
JF - Trends in Cardiovascular Medicine
IS - 1
ER -