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The role of human cytochrome P450 2E1 in liver inflammation and fibrosis
Jun Xu
, Hsiao Yen Ma
, Shuang Liang
, Mengxi Sun
, Gabriel Karin
, Yukinori Koyama
, Ronglin Hu
, Oswald Quehenberger
,
Nicholas O. Davidson
, Edward A. Dennis
, Tatiana Kisseleva
, David A. Brenner
Department of Medicine
Bursky Center for Human Immunology and Immunotherapy
Center of Regenerative Medicine
Roy and Diana Vagelos Division of Biology & Biomedical Sciences (DBBS)
Division of Gastroenterology
Institute of Clinical and Translational Sciences (ICTS)
Rheumatic Diseases Research Resource-Based Center
Siteman Cancer Center
DBBS - Molecular Cell Biology
DBBS - Biomedical Informatics and Data Science
DBBS - Biochemistry, Biophysics, and Structural Biology
Research output
:
Contribution to journal
›
Article
›
peer-review
71
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Scopus citations
Overview
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Keyphrases
Liver Fibrosis
100%
Liver Inflammation
100%
Cytochrome P450 2E1 (CYP2E1)
100%
CYP2E1 Gene
100%
Human Cytochrome P450
100%
Wild Mice
50%
Hepatic Steatosis
33%
Reactive Oxygen Species
33%
Hepatic Stellate Cell Activation
33%
Inflammatory Genes
33%
Diacylglycerol
16%
Free Fatty Acids
16%
Inflammation
16%
Fibrosis
16%
Liver Injury
16%
Alcoholic Liver Disease
16%
Genotype
16%
Carbon Tetrachloride
16%
Decreased Expression
16%
Fatty Acid Esters
16%
Lipidomics
16%
Lipid Peroxidation
16%
Bile Duct Ligation
16%
Toxin Production
16%
Prostaglandins
16%
Hepatocyte Injury
16%
Inflammatory Fibrosis
16%
Fibrogenic
16%
Hepatology
16%
In the Wild
16%
Alcohol-induced
16%
Induced Oxidative Stress
16%
Triacylglycerol
16%
Alcohol Feeding
16%
Cholesterol Ester
16%
Polar Metabolites
16%
Hepatocyte Death
16%
Alcohol Metabolism
16%
Cholestatic Liver Injury
16%
Lipogenic Genes
16%
Cholestatic Fibrosis
16%
Medicine and Dentistry
Liver Fibrosis
100%
CYP2E1
100%
Fibrosis
27%
Reactive Oxygen Species
18%
Hepatic Stellate Cell
18%
Fatty Liver
18%
Cell Activation
9%
Liver Injury
9%
Triacylglycerol
9%
Carbon Tetrachloride
9%
Fibrogenesis
9%
Oxidative Stress
9%
Fatty Acid
9%
Metabolite
9%
Liver Cell Damage
9%
Diacylglycerol
9%
Hepatology
9%
Prostaglandin
9%
Bile Duct Ligation
9%
Lipid Peroxidation
9%
Cholesterol Ester
9%
Alcohol Liver Disease
9%
Lipidomics
9%
Fatty Acid Ester
9%
Pharmacology, Toxicology and Pharmaceutical Science
Liver Fibrosis
100%
CYP2E1
100%
Wild Type Mouse
27%
Fibrosis
27%
Inflammation
18%
Reactive Oxygen Metabolite
18%
Fatty Liver
18%
Liver Injury
9%
Carbon Tetrachloride
9%
Fatty Acid
9%
Triacylglycerol
9%
Liver Cell Damage
9%
Fatty Acid Ester
9%
Diacylglycerol
9%
Prostaglandin
9%
Cholesterol Ester
9%
Alcohol Liver Disease
9%
Immunology and Microbiology
Cytochrome P450
100%
Wild Type Mouse
60%
Hepatic Stellate Cell
40%
Cell Activation
20%
Wild Type
20%
Oxidative Stress
20%
Fibrogenesis
20%
Metabolite
20%
Prostaglandin
20%
Lipid Peroxidation
20%
Bile Duct
20%
Hepatology
20%
Fatty Acid
20%
Biochemistry, Genetics and Molecular Biology
CYP2E1
100%
Wild Type Mouse
27%
Hepatic Stellate Cell
18%
Wild Type
9%
Metabolic Pathway
9%
Triglyceride
9%
Metabolite
9%
Oxidative Stress
9%
Cell Activation
9%
Hepatocyte
9%
Free Fatty Acids
9%
Lipidomics
9%
Nested Gene
9%
Fibrogenesis
9%
Lipid Peroxidation
9%
Diglyceride
9%
Prostaglandin
9%