TY - JOUR
T1 - The role of growth factors in intestinal regeneration and repair in necrotizing enterocolitis
AU - Rowland, Kathryn J.
AU - Choi, Pamela M.
AU - Warner, Brad W.
PY - 2013/5
Y1 - 2013/5
N2 - Necrotizing enterocolitis (NEC) is a devastating intestinal disease resulting in major neonatal morbidity and mortality. The pathology is poorly understood, and the means of preventing and treating NEC are limited. Several endogenous growth factors have been identified as having important roles in intestinal growth as well as aiding intestinal repair from injury or inflammation. In this review, we will discuss several growth factors as mediators of intestinal regeneration and repair as well as potential therapeutic agents for NEC.
AB - Necrotizing enterocolitis (NEC) is a devastating intestinal disease resulting in major neonatal morbidity and mortality. The pathology is poorly understood, and the means of preventing and treating NEC are limited. Several endogenous growth factors have been identified as having important roles in intestinal growth as well as aiding intestinal repair from injury or inflammation. In this review, we will discuss several growth factors as mediators of intestinal regeneration and repair as well as potential therapeutic agents for NEC.
KW - Epidermal growth factor
KW - Glucagon-like peptide-2
KW - Growth hormone
KW - Hepatocyte growth factor
KW - Insulin-like growth factor
KW - Necrotizing enterocolitis
UR - http://www.scopus.com/inward/record.url?scp=84876741426&partnerID=8YFLogxK
U2 - 10.1053/j.sempedsurg.2013.01.007
DO - 10.1053/j.sempedsurg.2013.01.007
M3 - Article
C2 - 23611614
AN - SCOPUS:84876741426
SN - 1055-8586
VL - 22
SP - 101
EP - 111
JO - Seminars in Pediatric Surgery
JF - Seminars in Pediatric Surgery
IS - 2
ER -