The role of growth factors in intestinal regeneration and repair in necrotizing enterocolitis

Kathryn J. Rowland, Pamela M. Choi, Brad W. Warner

Research output: Contribution to journalArticlepeer-review

33 Scopus citations

Abstract

Necrotizing enterocolitis (NEC) is a devastating intestinal disease resulting in major neonatal morbidity and mortality. The pathology is poorly understood, and the means of preventing and treating NEC are limited. Several endogenous growth factors have been identified as having important roles in intestinal growth as well as aiding intestinal repair from injury or inflammation. In this review, we will discuss several growth factors as mediators of intestinal regeneration and repair as well as potential therapeutic agents for NEC.

Original languageEnglish
Pages (from-to)101-111
Number of pages11
JournalSeminars in pediatric surgery
Volume22
Issue number2
DOIs
StatePublished - May 2013

Keywords

  • Epidermal growth factor
  • Glucagon-like peptide-2
  • Growth hormone
  • Hepatocyte growth factor
  • Insulin-like growth factor
  • Necrotizing enterocolitis

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