The role of growth factors, cytokines, and vasoactive compounds in obstructive nephropathy

Saulo Klahr, Jeremiah J. Morrissey

Research output: Contribution to journalReview articlepeer-review

86 Scopus citations

Abstract

Renal interstitial inflammation and fibrosis occurs after ureteral obstruction. Fibrosis most likely develops as a consequence of an imbalance between extracellular matrix synthesis and deposition and the degradation and removal of matrix. Angiotensin II is rapidly stimulated after the onset of ureteral obstruction. Angiotensin II in turn upregulates other factors (transforming growth factor β, tumor necrosis factor-α, nuclear factor- κB, and several adhesion molecules and chemoattractants). Blockade of angiotensin II synthesis or inability of this peptide to bind to its receptor lessened the increased levels of mRNA for TGF-β and collagen IV. Increased levels of angiotensin II have a major role in the development of tubulointerstitial fibrosis after ureteral obstruction.

Original languageEnglish
Pages (from-to)622-632
Number of pages11
JournalSeminars in Nephrology
Volume18
Issue number6
StatePublished - 1998

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