TY - JOUR
T1 - The Role of Fecal Microbiota Transplantation in Reducing Intestinal Colonization with Antibiotic-Resistant Organisms
T2 - The Current Landscape and Future Directions
AU - Woodworth, Michael H.
AU - Hayden, Mary K.
AU - Young, Vincent B.
AU - Kwon, Jennie H.
N1 - Publisher Copyright:
© 2019 The Author(s) 2019. Published by Oxford University Press on behalf of Infectious Diseases Society of America.
PY - 2019/7/1
Y1 - 2019/7/1
N2 - The intestinal tract is a recognized reservoir of antibiotic-resistant organisms (ARO), and a potential target for strategies to reduce ARO colonization. Microbiome therapies such as fecal microbiota transplantation (FMT) have been established as an effective treatment for recurrent Clostridioides difficile infection and may be an effective approach for reducing intestinal ARO colonization. In this article, we review the current published literature on the role of FMT for eradication of intestinal ARO colonization, review the potential benefit and limitations of the use of FMT in this setting, and outline a research agenda for the future study of FMT for intestinal ARO colonization.
AB - The intestinal tract is a recognized reservoir of antibiotic-resistant organisms (ARO), and a potential target for strategies to reduce ARO colonization. Microbiome therapies such as fecal microbiota transplantation (FMT) have been established as an effective treatment for recurrent Clostridioides difficile infection and may be an effective approach for reducing intestinal ARO colonization. In this article, we review the current published literature on the role of FMT for eradication of intestinal ARO colonization, review the potential benefit and limitations of the use of FMT in this setting, and outline a research agenda for the future study of FMT for intestinal ARO colonization.
KW - antibiotic resistance
KW - antibiotic-resistant organism
KW - fecal microbiota transplantation
KW - hospital epidemiology
KW - microbiome
KW - multidrug-resistant organisms
KW - resistome
UR - http://www.scopus.com/inward/record.url?scp=85078740947&partnerID=8YFLogxK
U2 - 10.1093/ofid/ofz288
DO - 10.1093/ofid/ofz288
M3 - Review article
C2 - 31363779
AN - SCOPUS:85078740947
SN - 2328-8957
VL - 6
JO - Open Forum Infectious Diseases
JF - Open Forum Infectious Diseases
IS - 7
ER -