The Role of Fecal Microbiota Transplantation in Reducing Intestinal Colonization with Antibiotic-Resistant Organisms: The Current Landscape and Future Directions

Michael H. Woodworth, Mary K. Hayden, Vincent B. Young, Jennie H. Kwon

Research output: Contribution to journalReview articlepeer-review

29 Scopus citations

Abstract

The intestinal tract is a recognized reservoir of antibiotic-resistant organisms (ARO), and a potential target for strategies to reduce ARO colonization. Microbiome therapies such as fecal microbiota transplantation (FMT) have been established as an effective treatment for recurrent Clostridioides difficile infection and may be an effective approach for reducing intestinal ARO colonization. In this article, we review the current published literature on the role of FMT for eradication of intestinal ARO colonization, review the potential benefit and limitations of the use of FMT in this setting, and outline a research agenda for the future study of FMT for intestinal ARO colonization.

Original languageEnglish
JournalOpen Forum Infectious Diseases
Volume6
Issue number7
DOIs
StatePublished - Jul 1 2019

Keywords

  • antibiotic resistance
  • antibiotic-resistant organism
  • fecal microbiota transplantation
  • hospital epidemiology
  • microbiome
  • multidrug-resistant organisms
  • resistome

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