TY - JOUR
T1 - The role of FDG-PET/CT in cervical cancer
T2 - Diagnosis, staging, radiation treatment planning and follow-up
AU - Haynes-Outlaw, Elesyia D.
AU - Grigsby, Perry W.
N1 - Funding Information:
This work was supported by Grant 5 KL2 RRO24983-03 from the National Center for Research Resources, a component of the National Institutes of Health .
PY - 2010/10
Y1 - 2010/10
N2 - Routine screening has lead to significant improvement in the incidence and mortality of cervical cancer in industrialized nations. Current International Federation of Gynecologists and Obstetricians staging is based mainly on clinical examination, with anatomic conventional imaging modalities, such as CT and MR imaging, also being routinely used. Metabolic imaging using 18F-fluoro-2-deoxy-D-glucose(FDG)-PET provides highly specific, noninvasive pretreatment staging and prognostic information regarding post-therapy, and can detect asymptomatic, potentially curable locoregional recurrences. FDG-PET/CT can also optimize the use of advanced radiation treatment planning techniques, such as image-guided intensity modulated radiation therapy, for cervical cancer and may be of value in the development of additional novel approaches, such as stereotactic body radiation therapy.
AB - Routine screening has lead to significant improvement in the incidence and mortality of cervical cancer in industrialized nations. Current International Federation of Gynecologists and Obstetricians staging is based mainly on clinical examination, with anatomic conventional imaging modalities, such as CT and MR imaging, also being routinely used. Metabolic imaging using 18F-fluoro-2-deoxy-D-glucose(FDG)-PET provides highly specific, noninvasive pretreatment staging and prognostic information regarding post-therapy, and can detect asymptomatic, potentially curable locoregional recurrences. FDG-PET/CT can also optimize the use of advanced radiation treatment planning techniques, such as image-guided intensity modulated radiation therapy, for cervical cancer and may be of value in the development of additional novel approaches, such as stereotactic body radiation therapy.
KW - Cancer staging
KW - Cervical cancer
KW - PET
KW - Radiotherapy treatment planning
UR - http://www.scopus.com/inward/record.url?scp=78649338442&partnerID=8YFLogxK
U2 - 10.1016/j.cpet.2010.07.004
DO - 10.1016/j.cpet.2010.07.004
M3 - Review article
C2 - 27157971
AN - SCOPUS:78649338442
SN - 1556-8598
VL - 5
SP - 435
EP - 446
JO - PET Clinics
JF - PET Clinics
IS - 4
ER -