The role of Fas ligand in vivo as a cause and regulator of pathogenesis

Kimberly A. Sabelko-Downes, John H. Russell

Research output: Contribution to journalReview articlepeer-review

26 Scopus citations


Recent studies have significantly advanced our understanding of the physiological and pathogenic functions of Fas and Fas ligand (FasL) in vivo. In particular, roles for Fas-FasL interactions both in the induction and regulation of organ-specific autoimmune diseases have been defined and in some cases the specific targets and effectors of these interactions have been identified. Understanding the dynamic role of the Fas-FasL pathway in autoimmunity will provide insight into how best to modulate this interaction to achieve therapeutic benefits.

Original languageEnglish
Pages (from-to)330-335
Number of pages6
JournalCurrent Opinion in Immunology
Issue number3
StatePublished - Jun 1 2000


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