TY - JOUR
T1 - The role of Fas ligand in vivo as a cause and regulator of pathogenesis
AU - Sabelko-Downes, Kimberly A.
AU - Russell, John H.
N1 - Funding Information:
This work was supported in part by grants from the Multiple Sclerosis Society (RG2835), The National Institute of Allergy and Infectious Diseases (AI07163) and the National Cancer Institute (CA28533).
PY - 2000/6/1
Y1 - 2000/6/1
N2 - Recent studies have significantly advanced our understanding of the physiological and pathogenic functions of Fas and Fas ligand (FasL) in vivo. In particular, roles for Fas-FasL interactions both in the induction and regulation of organ-specific autoimmune diseases have been defined and in some cases the specific targets and effectors of these interactions have been identified. Understanding the dynamic role of the Fas-FasL pathway in autoimmunity will provide insight into how best to modulate this interaction to achieve therapeutic benefits.
AB - Recent studies have significantly advanced our understanding of the physiological and pathogenic functions of Fas and Fas ligand (FasL) in vivo. In particular, roles for Fas-FasL interactions both in the induction and regulation of organ-specific autoimmune diseases have been defined and in some cases the specific targets and effectors of these interactions have been identified. Understanding the dynamic role of the Fas-FasL pathway in autoimmunity will provide insight into how best to modulate this interaction to achieve therapeutic benefits.
UR - http://www.scopus.com/inward/record.url?scp=0034053281&partnerID=8YFLogxK
U2 - 10.1016/S0952-7915(00)00095-9
DO - 10.1016/S0952-7915(00)00095-9
M3 - Review article
C2 - 10781398
AN - SCOPUS:0034053281
VL - 12
SP - 330
EP - 335
JO - Current Opinion in Immunology
JF - Current Opinion in Immunology
SN - 0952-7915
IS - 3
ER -