The role of fas ligand in immune privilege

Douglas R. Green, Thomas A. Ferguson

Research output: Contribution to journalReview article

196 Scopus citations

Abstract

Immune privilege is a property of some sites in the body, whereby immune responses are limited or prevented. One explanation that has been proposed for this phenomenon is engagement of the pro-apoptotic molecule Fas by its ligand (FasL), which leads to apoptosis, and consequently limits an inflammatory response. This idea has recently been challenged, and here we review the evidence for and against a role for FasL in immune privilege.

Original languageEnglish
Pages (from-to)917-924
Number of pages8
JournalNature Reviews Molecular Cell Biology
Volume2
Issue number12
DOIs
StatePublished - Dec 1 2001

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