107 Scopus citations

Abstract

Dendritic cells (DCs) are known to play a central role in sensing the presence of foreign antigens and infectious agents and in initiating appropriate immune responses. More recently, an additional role has been discovered for DCs in determining whether the response to potential environmental allergens will be one of tolerance or whether a vigorous response along allergic pathways will be initiated. This review discusses ways in which DCs participate specifically in initiating allergic responses, particularly those associated with allergic asthma, and how interventions focused on DCs might lead to new therapeutic approaches to asthma.

Original languageEnglish
Pages (from-to)889-901
Number of pages13
JournalJournal of Allergy and Clinical Immunology
Volume129
Issue number4
DOIs
StatePublished - Apr 2012

Keywords

  • allergen
  • asthma
  • Dendritic cells
  • T 2 inflammation

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