The role of cytokines in the initiation, expansion, and control of cellular immunity to tuberculosis

Andrea M. Cooper, Shabaana A. Khader

Research output: Contribution to journalReview article

222 Scopus citations

Abstract

Tuberculosis (TB) results from an interaction between a potent immune response and a chronically persistent pathogen. The ability of Mycobacterium tuberculosis (Mtb) to induce a strong immune response while being able to resist the ability of the host to clear bacteria provides an excellent tool with which to investigate the role of specific cytokine pathways on the induction, expansion, and control of the effector T-cell response. In this review, the role of interleukin-12p40 (IL-12p40), IL-12p70, IL-23, and IL-27 in the immune response to Mtb are described. We show that IL-12(p40)2 acts to mediate the activation of dendritic cells to become responsive to homeostatic chemokines. We also show that IL-12p70 is required for the optimal interferon-γ (IFN-γ) T-cell response, which is required for control of Mtb growth. IL-23 can induce IFN-γ responses in the lung if IL-12 is not present, but its major role is in supporting the IL-17 response within the lung. Neither IL-23 nor IL-17 is required for early control of Mtb in the lung. IL-23 and IL-17, however, can be instrumental in vaccine-induced protection. Finally, IL-27 limits protective immunity in the lung, but it is also required for long-term survival. These cytokines are therefore key players in the immune response to TB.

Original languageEnglish
Pages (from-to)191-204
Number of pages14
JournalImmunological Reviews
Volume226
Issue number1
DOIs
StatePublished - Dec 1 2008
Externally publishedYes

Keywords

  • Cell activation
  • Cytokine
  • Infectious disease
  • Lung
  • Memory
  • Th1/Th2/Th17

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