The role of cytokines in radiation oncology.

D. E. Hallahan, A. Haimovitz-Friedman, D. W. Kufe, Z. Fuks, R. R. Weichselbaum

Research output: Contribution to journalReview articlepeer-review

58 Scopus citations

Abstract

Cytokine induction following ionizing radiation exposure occurs through transcriptional activation in specific proteins studied to date. This process can be blocked by inhibition of radiation-induced signaling pathways, which may potentially modify certain deleterious effects of radiotherapy, e.g., effects related to production of TNF or TGF-beta. bFGF is another radiation-inducible protein that may participate in repair and protection of irradiated endothelial cells following a complex interaction with cellular receptors. The cytokines such as IL-6, TNF, and IL-1 may be useful to protect hematopoietic cells from radiation, while TNF may enhance the killing of tumor cells. Our understanding of cytokine/radiation interactions is only beginning to be understood, but knowledge of the biology of these interactions may prove clinically useful.

Original languageEnglish
Pages (from-to)71-80
Number of pages10
JournalImportant advances in oncology
StatePublished - Jan 1 1993

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