TY - JOUR
T1 - The role of CT-quantified body composition on longitudinal health-related quality of life in colorectal cancer patients
T2 - The colocare study
AU - Gigic, Biljana
AU - Nattenmüller, Johanna
AU - Schneider, Martin
AU - Kulu, Yakup
AU - Syrjala, Karen L.
AU - Böhm, Jürgen
AU - Schrotz-King, Petra
AU - Brenner, Hermann
AU - Colditz, Graham A.
AU - Figueiredo, Jane C.
AU - Grady, William M.
AU - Li, Christopher I.
AU - Shibata, David
AU - Siegel, Erin M.
AU - Toriola, Adetunji T.
AU - Kauczor, Hans Ulrich
AU - Ulrich, Alexis
AU - Ulrich, Cornelia M.
N1 - Publisher Copyright:
© 2020 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2020/5
Y1 - 2020/5
N2 - Background: Obesity, defined by body mass index (BMI), measured at colorectal cancer (CRC) diagnosis has been associated with postoperative complications and survival outcomes. However, BMI does not allow for a differentiation between fat and muscle mass. Computed tomography (CT)-defined body composition more accurately reflects different types of tissue and their associations with health-related quality of life (HRQoL) during the first year of disease, but this has not been investigated yet. We studied the role of visceral and subcutaneous fat area (VFA and SFA) and skeletal muscle mass (SMM) on longitudinally assessed HRQoL in CRC patients. Methods: A total of 138 newly diagnosed CRC patients underwent CT scans at diagnosis and completed questionnaires prior to and six and twelve months post-surgery. We investigated the associations of VFA, SFA, and SMM with HRQoL at multiple time points. Results: A higher VFA was associated with increased pain six and twelve months post-surgery (β = 0.06, p = 0.04 and β = 0.07, p = 0.01) and with worse social functioning six months post-surgery (β = −0.08, p = 0.01). Higher SMM was associated with increased pain twelve months post-surgery (β = 1.03, p < 0.01). Conclusions: CT-quantified body composition is associated with HRQoL scales post-surgery. Intervention strategies targeting a reduction in VFA and maintaining SMM might improve HRQoL in CRC patients during the first year post-surgery.
AB - Background: Obesity, defined by body mass index (BMI), measured at colorectal cancer (CRC) diagnosis has been associated with postoperative complications and survival outcomes. However, BMI does not allow for a differentiation between fat and muscle mass. Computed tomography (CT)-defined body composition more accurately reflects different types of tissue and their associations with health-related quality of life (HRQoL) during the first year of disease, but this has not been investigated yet. We studied the role of visceral and subcutaneous fat area (VFA and SFA) and skeletal muscle mass (SMM) on longitudinally assessed HRQoL in CRC patients. Methods: A total of 138 newly diagnosed CRC patients underwent CT scans at diagnosis and completed questionnaires prior to and six and twelve months post-surgery. We investigated the associations of VFA, SFA, and SMM with HRQoL at multiple time points. Results: A higher VFA was associated with increased pain six and twelve months post-surgery (β = 0.06, p = 0.04 and β = 0.07, p = 0.01) and with worse social functioning six months post-surgery (β = −0.08, p = 0.01). Higher SMM was associated with increased pain twelve months post-surgery (β = 1.03, p < 0.01). Conclusions: CT-quantified body composition is associated with HRQoL scales post-surgery. Intervention strategies targeting a reduction in VFA and maintaining SMM might improve HRQoL in CRC patients during the first year post-surgery.
KW - CT-quantified body composition
KW - Colorectal cancer
KW - Health-related quality of life
KW - Prospective data
KW - Skeletal muscle mass
KW - Subcutaneous fat area
KW - Visceral fat area
UR - http://www.scopus.com/inward/record.url?scp=85083994784&partnerID=8YFLogxK
U2 - 10.3390/nu12051247
DO - 10.3390/nu12051247
M3 - Article
C2 - 32353960
AN - SCOPUS:85083994784
SN - 2072-6643
VL - 12
JO - Nutrients
JF - Nutrients
IS - 5
M1 - 1247
ER -