TY - JOUR
T1 - The role of CT-quantified body composition on longitudinal health-related quality of life in colorectal cancer patients
T2 - The colocare study
AU - Gigic, Biljana
AU - Nattenmüller, Johanna
AU - Schneider, Martin
AU - Kulu, Yakup
AU - Syrjala, Karen L.
AU - Böhm, Jürgen
AU - Schrotz-King, Petra
AU - Brenner, Hermann
AU - Colditz, Graham A.
AU - Figueiredo, Jane C.
AU - Grady, William M.
AU - Li, Christopher I.
AU - Shibata, David
AU - Siegel, Erin M.
AU - Toriola, Adetunji T.
AU - Kauczor, Hans Ulrich
AU - Ulrich, Alexis
AU - Ulrich, Cornelia M.
N1 - Funding Information:
Biljana Gigic was funded by the Stiftung Lebensblicke, Matthias Lackas Foundation, the ERA-NET on Translational Cancer Research (TRANSCAN) project 01KT1503 (FOCUS consortium), and the National Cancer Institute project R01 CA189184. Dr. Cornelia M Ulrich was funded by the National Cancer Institute projects NIH R01 CA 189184 and NIH U01 CA 206110 and the Huntsman Cancer Foundation. Dr. Ulrich was further funded by NIH R01 CA207371 and P30 CA042014. Dr. Jane C. Figueiredo was funded by National Cancer Institute project NIH U01 CA 206110. The Heidelberg ColoCare Study was supported by the Matthias Lackas Foundation, the German Consortium of Translational Cancer Research (DKTK) and the TRANSCAN grant 01KT1503 and institutional funding from the Division of General, Visceral and Transplantation Surgery, University of Heidelberg, the German Cancer Research Center (DKFZ), and the Division of Preventive Oncology (Dr. Cornelia M. Ulrich, Dr. Hermann Brenner) at the National Center for Tumor Diseases (NCT), Heidelberg, Germany. Dr. Syrjala was funded by the National Cancer Institute R01 CA160684 and R01 CA215134.
Funding Information:
Funding: Biljana Gigic was funded by the Stiftung Lebensblicke, Matthias Lackas Foundation, the ERA-NET on Translational Cancer Research (TRANSCAN) project 01KT1503 (FOCUS consortium), and the National Cancer Institute project R01 CA189184. Dr. Cornelia M Ulrich was funded by the National Cancer Institute projects NIH R01 CA 189184 and NIH U01 CA 206110 and the Huntsman Cancer Foundation. Dr. Ulrich was further funded by NIH R01 CA207371 and P30 CA042014. Dr. Jane C. Figueiredo was funded by National Cancer Institute project NIH U01 CA 206110. The Heidelberg ColoCare Study was supported by the Matthias Lackas Foundation, the German Consortium of Translational Cancer Research (DKTK) and the TRANSCAN grant 01KT1503 and institutional funding from the Division of General, Visceral and Transplantation Surgery, University of Heidelberg, the German Cancer Research Center (DKFZ), and the Division of Preventive Oncology (Dr. Cornelia M. Ulrich, Dr. Hermann Brenner) at the National Center for Tumor Diseases (NCT), Heidelberg, Germany. Dr. Syrjala was funded by the National Cancer Institute R01 CA160684 and R01 CA215134.
Publisher Copyright:
© 2020 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2020/5
Y1 - 2020/5
N2 - Background: Obesity, defined by body mass index (BMI), measured at colorectal cancer (CRC) diagnosis has been associated with postoperative complications and survival outcomes. However, BMI does not allow for a differentiation between fat and muscle mass. Computed tomography (CT)-defined body composition more accurately reflects different types of tissue and their associations with health-related quality of life (HRQoL) during the first year of disease, but this has not been investigated yet. We studied the role of visceral and subcutaneous fat area (VFA and SFA) and skeletal muscle mass (SMM) on longitudinally assessed HRQoL in CRC patients. Methods: A total of 138 newly diagnosed CRC patients underwent CT scans at diagnosis and completed questionnaires prior to and six and twelve months post-surgery. We investigated the associations of VFA, SFA, and SMM with HRQoL at multiple time points. Results: A higher VFA was associated with increased pain six and twelve months post-surgery (β = 0.06, p = 0.04 and β = 0.07, p = 0.01) and with worse social functioning six months post-surgery (β = −0.08, p = 0.01). Higher SMM was associated with increased pain twelve months post-surgery (β = 1.03, p < 0.01). Conclusions: CT-quantified body composition is associated with HRQoL scales post-surgery. Intervention strategies targeting a reduction in VFA and maintaining SMM might improve HRQoL in CRC patients during the first year post-surgery.
AB - Background: Obesity, defined by body mass index (BMI), measured at colorectal cancer (CRC) diagnosis has been associated with postoperative complications and survival outcomes. However, BMI does not allow for a differentiation between fat and muscle mass. Computed tomography (CT)-defined body composition more accurately reflects different types of tissue and their associations with health-related quality of life (HRQoL) during the first year of disease, but this has not been investigated yet. We studied the role of visceral and subcutaneous fat area (VFA and SFA) and skeletal muscle mass (SMM) on longitudinally assessed HRQoL in CRC patients. Methods: A total of 138 newly diagnosed CRC patients underwent CT scans at diagnosis and completed questionnaires prior to and six and twelve months post-surgery. We investigated the associations of VFA, SFA, and SMM with HRQoL at multiple time points. Results: A higher VFA was associated with increased pain six and twelve months post-surgery (β = 0.06, p = 0.04 and β = 0.07, p = 0.01) and with worse social functioning six months post-surgery (β = −0.08, p = 0.01). Higher SMM was associated with increased pain twelve months post-surgery (β = 1.03, p < 0.01). Conclusions: CT-quantified body composition is associated with HRQoL scales post-surgery. Intervention strategies targeting a reduction in VFA and maintaining SMM might improve HRQoL in CRC patients during the first year post-surgery.
KW - CT-quantified body composition
KW - Colorectal cancer
KW - Health-related quality of life
KW - Prospective data
KW - Skeletal muscle mass
KW - Subcutaneous fat area
KW - Visceral fat area
UR - http://www.scopus.com/inward/record.url?scp=85083994784&partnerID=8YFLogxK
U2 - 10.3390/nu12051247
DO - 10.3390/nu12051247
M3 - Article
C2 - 32353960
AN - SCOPUS:85083994784
SN - 2072-6643
VL - 12
JO - Nutrients
JF - Nutrients
IS - 5
M1 - 1247
ER -