The role of chemokines in term and premature rupture of the fetal membranes: A review

Nardhy Gomez-Lopez, Estibalitz Laresgoiti-Servitje, David M. Olson, Guadalupe Estrada-Gutiérrez, Felipe Vadillo-Ortega

Research output: Contribution to journalShort surveypeer-review

82 Scopus citations


Several studies indicate that at the choriodecidual interface, where maternal and fetal tissues make contact, a network of signals is established during labor that includes infiltration of leukocytes and secretion of pro-inflammatory cytokines. In this review, we provide an overview of the inflammatory milieu present in the choriodecidua during membrane rupture, describe the recruitment and homing of leukocytes to the reproductive tissues, and detail specific actions of the key chemokines released by the choriodecidual cells. These data lend further support to the hypothesis that labor is an inflammatory response, wherein the infiltrated leukocytes in the choriodecidua interface could be contributing to the creation of a microenvironment leading to collagenolysis, which would promote the rupture of these tissues during labor. In addition to the available information describing biological actions of chemokines during various pathological conditions such as infection, preterm labor and preterm rupture of membranes suggest that these compounds play important roles in other gestational events such as cervical dilation and myometrial contractions. Even though we do not know the totality of biochemical signals that integrate the molecular dialogue between leukocytes and the various gestational tissues, it is becoming increasingly evident that this microenvironment is characterized, at least in part, by the differential expression and secretion of chemokines that induce selective trafficking of leukocyte subsets to the fetal membranes. Therefore, chemokines should be considered as important regulatory molecules with the ability to initiate the events that characterize normal and pathological labor.

Original languageEnglish
Pages (from-to)809-814
Number of pages6
JournalBiology of reproduction
Issue number5
StatePublished - May 2010


  • Chemokines
  • Cytokines
  • Decidua
  • Delivery
  • Labor
  • Parturition
  • Pregnancy


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