The role of cDC1s in vivo: CD8 T cell priming through cross-presentation

Kenneth Murphy, Derek Theisen

Research output: Contribution to journalReview articlepeer-review

28 Scopus citations

Abstract

The cDC1 subset of classical dendritic cells is specialized for priming CD8 T cell responses through the process of cross-presentation. The molecular mechanisms of cross-presentation remain incompletely understood because of limited biochemical analysis of rare cDC1 cells, difficulty in their genetic manipulation, and reliance on in vitro systems based on monocyte- and bone-marrow-derived dendritic cells. This review will discuss cross-presentation from the perspective of studies with monocyte- or bone-marrow-derived dendritic cells while highlighting the need for future work examining cDC1 cells. We then discuss the role of cDC1s as a cellular platform to combine antigen processing for class I and class II MHC presentation to allow the integration of "help" from CD4 T cells during priming of CD8 T cell responses.

Original languageEnglish
Article number98
JournalF1000Research
Volume6
DOIs
StatePublished - 2017

Keywords

  • Dendritic cell
  • Monocyte-derived dendritic cells
  • T cell response

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