TY - JOUR
T1 - The role of brown adipose tissue in branched-chain amino acid clearance in people
AU - Abdelhafez, Yasser G.
AU - Wang, Guobao
AU - Li, Siqi
AU - Pellegrinelli, Vanessa
AU - Chaudhari, Abhijit J.
AU - Ramirez, Anthony
AU - Sen, Fatma
AU - Vidal-Puig, Antonio
AU - Sidossis, Labros S.
AU - Klein, Samuel
AU - Badawi, Ramsey D.
AU - Chondronikola, Maria
N1 - Publisher Copyright:
© 2024 The Authors
PY - 2024/8/16
Y1 - 2024/8/16
N2 - Brown adipose tissue (BAT) in rodents appears to be an important tissue for the clearance of plasma branched-chain amino acids (BCAAs) contributing to improved metabolic health. However, the role of human BAT in plasma BCAA clearance is poorly understood. Here, we evaluate patients with prostate cancer who underwent positron emission tomography-computed tomography imaging after an injection of 18F-fluciclovine (L-leucine analog). Supraclavicular adipose tissue (AT; primary location of human BAT) has a higher net uptake rate for 18F-fluciclovine compared to subcutaneous abdominal and upper chest AT. Supraclavicular AT 18F-fluciclovine net uptake rate is lower in patients with obesity and type 2 diabetes. Finally, the expression of genes involved in BCAA catabolism is higher in the supraclavicular AT of healthy people with high BAT volume compared to those with low BAT volume. These findings support the notion that BAT can potentially function as a metabolic sink for plasma BCAA clearance in people.
AB - Brown adipose tissue (BAT) in rodents appears to be an important tissue for the clearance of plasma branched-chain amino acids (BCAAs) contributing to improved metabolic health. However, the role of human BAT in plasma BCAA clearance is poorly understood. Here, we evaluate patients with prostate cancer who underwent positron emission tomography-computed tomography imaging after an injection of 18F-fluciclovine (L-leucine analog). Supraclavicular adipose tissue (AT; primary location of human BAT) has a higher net uptake rate for 18F-fluciclovine compared to subcutaneous abdominal and upper chest AT. Supraclavicular AT 18F-fluciclovine net uptake rate is lower in patients with obesity and type 2 diabetes. Finally, the expression of genes involved in BCAA catabolism is higher in the supraclavicular AT of healthy people with high BAT volume compared to those with low BAT volume. These findings support the notion that BAT can potentially function as a metabolic sink for plasma BCAA clearance in people.
KW - Cancer
KW - Human genetics
KW - Human metabolism
UR - https://www.scopus.com/pages/publications/85199924389
U2 - 10.1016/j.isci.2024.110559
DO - 10.1016/j.isci.2024.110559
M3 - Article
C2 - 39175781
AN - SCOPUS:85199924389
SN - 2589-0042
VL - 27
JO - iScience
JF - iScience
IS - 8
M1 - 110559
ER -