The Role of Biomarkers in the Diagnosis and Risk Stratification of Acute Graft-versus-Host Disease: A Systematic Review

Research output: Contribution to journalReview article

30 Scopus citations

Abstract

Allogeneic hematopoietic cell transplantation (HCT) is an increasingly used curative modality for hematologic malignancies and other benign conditions. Attempts to reduce morbidity and mortality and improve survival in patients undergoing HCT are crucial. The ability to diagnose acute graft-versus-host disease (aGVHD) in a timely manner, or to even predict aGVHD before clinical manifestations, along with the accurate stratification of these patients, are critical steps to improve the treatment and outcomes of these patients. Many novel biomarkers that may help achieve these goals have been studied recently. This overview is intended to assist clinicians and investigators by providing a comprehensive review and analytical interpretation of the current knowledge concerning aGVHD and biomarkers likely to prove useful in diagnosis and risk stratification of this condition, along with the difficulties that hamper this approach.

Original languageEnglish
Pages (from-to)1552-1564
Number of pages13
JournalBiology of Blood and Marrow Transplantation
Volume22
Issue number9
DOIs
StatePublished - Sep 1 2016

Keywords

  • Biomarker
  • Graft-versus-host disease
  • Hematopoietic stem cell transplantation
  • Proteomics

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