The risk of gallstones in middle-aged women

Richard L. Nelson; Victoria W. Persky; Faith G. Davis; K. J. Van Erpecum; G. P.Van Berge Henegouwen; Torben Jørgensen; Carlo la Vecchia; Eva Negri; Barbara D'avanzo; Peter Boyle; K. Malcolm Maclure; K. C. Hayes; Graham A. Colditz; Meir J. Stampfer; Frank E. Speizer; Walter C. Willett

doi:10.1056/NEJM199002153220713

The risk of gallstones in middle-aged women

Richard L. Nelson, Victoria W. Persky, Faith G. Davis, K. J. Van Erpecum, G. P.Van Berge Henegouwen, Torben Jørgensen, Carlo la Vecchia, Eva Negri, Barbara D'avanzo, Peter Boyle, K. Malcolm Maclure, K. C. Hayes, Graham A. Colditz, Meir J. Stampfer, Frank E. Speizer, Walter C. Willett

Research output: Contribution to journal › Letter › peer-review

Abstract

To the Editor: It was with some surprise that we read in the article by Maclure et al. (Aug. 31 issue)¹ that parity was not a risk factor in the development of symptomatic cholelithiasis in the Nurses' Health Study. Research on the pathophysiology of gallstone formation has focused in part on the effects of pregnancy as well as endogenous and exogenous estrogens on bile composition and the contractility of the gallbladder.² Existing epidemiologic data also suggest that hormones may affect the risk of cholelithiasis. Studies in women have noted positive associations of both parity and oral-contraceptive use with cholelithiasis, although.

Original language	English
Pages (from-to)	472-474
Number of pages	3
Journal	New England Journal of Medicine
Volume	322
Issue number	7
DOIs	https://doi.org/10.1056/NEJM199002153220713
State	Published - Feb 15 1990

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Nelson, R. L., Persky, V. W., Davis, F. G., Van Erpecum, K. J., Henegouwen, G. P. V. B., Jørgensen, T., la Vecchia, C., Negri, E., D'avanzo, B., Boyle, P., Maclure, K. M., Hayes, K. C., Colditz, G. A., Stampfer, M. J., Speizer, F. E., & Willett, W. C. (1990). The risk of gallstones in middle-aged women. New England Journal of Medicine, 322(7), 472-474. https://doi.org/10.1056/NEJM199002153220713

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abstract = "To the Editor: It was with some surprise that we read in the article by Maclure et al. (Aug. 31 issue)1 that parity was not a risk factor in the development of symptomatic cholelithiasis in the Nurses' Health Study. Research on the pathophysiology of gallstone formation has focused in part on the effects of pregnancy as well as endogenous and exogenous estrogens on bile composition and the contractility of the gallbladder.2 Existing epidemiologic data also suggest that hormones may affect the risk of cholelithiasis. Studies in women have noted positive associations of both parity and oral-contraceptive use with cholelithiasis, although.",

author = "Nelson, {Richard L.} and Persky, {Victoria W.} and Davis, {Faith G.} and {Van Erpecum}, {K. J.} and Henegouwen, {G. P.Van Berge} and Torben J{\o}rgensen and {la Vecchia}, Carlo and Eva Negri and Barbara D'avanzo and Peter Boyle and Maclure, {K. Malcolm} and Hayes, {K. C.} and Colditz, {Graham A.} and Stampfer, {Meir J.} and Speizer, {Frank E.} and Willett, {Walter C.}",

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doi = "10.1056/NEJM199002153220713",

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AU - Nelson, Richard L.

AU - Persky, Victoria W.

AU - Davis, Faith G.

AU - Van Erpecum, K. J.

AU - Henegouwen, G. P.Van Berge

AU - Jørgensen, Torben

AU - la Vecchia, Carlo

AU - Negri, Eva

AU - D'avanzo, Barbara

AU - Boyle, Peter

AU - Maclure, K. Malcolm

AU - Hayes, K. C.

AU - Colditz, Graham A.

AU - Stampfer, Meir J.

AU - Speizer, Frank E.

AU - Willett, Walter C.

PY - 1990/2/15

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N2 - To the Editor: It was with some surprise that we read in the article by Maclure et al. (Aug. 31 issue)1 that parity was not a risk factor in the development of symptomatic cholelithiasis in the Nurses' Health Study. Research on the pathophysiology of gallstone formation has focused in part on the effects of pregnancy as well as endogenous and exogenous estrogens on bile composition and the contractility of the gallbladder.2 Existing epidemiologic data also suggest that hormones may affect the risk of cholelithiasis. Studies in women have noted positive associations of both parity and oral-contraceptive use with cholelithiasis, although.

AB - To the Editor: It was with some surprise that we read in the article by Maclure et al. (Aug. 31 issue)1 that parity was not a risk factor in the development of symptomatic cholelithiasis in the Nurses' Health Study. Research on the pathophysiology of gallstone formation has focused in part on the effects of pregnancy as well as endogenous and exogenous estrogens on bile composition and the contractility of the gallbladder.2 Existing epidemiologic data also suggest that hormones may affect the risk of cholelithiasis. Studies in women have noted positive associations of both parity and oral-contraceptive use with cholelithiasis, although.

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ER -

The risk of gallstones in middle-aged women

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