The risk of gallstones in middle-aged women

Richard L. Nelson, Victoria W. Persky, Faith G. Davis, K. J. Van Erpecum, G. P.Van Berge Henegouwen, Torben Jørgensen, Carlo la Vecchia, Eva Negri, Barbara D'avanzo, Peter Boyle, K. Malcolm Maclure, K. C. Hayes, Graham A. Colditz, Meir J. Stampfer, Frank E. Speizer, Walter C. Willett

Research output: Contribution to journalLetterpeer-review


To the Editor: It was with some surprise that we read in the article by Maclure et al. (Aug. 31 issue)1 that parity was not a risk factor in the development of symptomatic cholelithiasis in the Nurses' Health Study. Research on the pathophysiology of gallstone formation has focused in part on the effects of pregnancy as well as endogenous and exogenous estrogens on bile composition and the contractility of the gallbladder.2 Existing epidemiologic data also suggest that hormones may affect the risk of cholelithiasis. Studies in women have noted positive associations of both parity and oral-contraceptive use with cholelithiasis, although.

Original languageEnglish
Pages (from-to)472-474
Number of pages3
JournalNew England Journal of Medicine
Issue number7
StatePublished - Feb 15 1990


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